Abstract：
The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively. In addition, extracellular proteases degrade or cleave matrix proteins, thereby contributing to ECM turnover. These interactions constitute the ECM interactome network, which is essential for maintaining vascular homeostasis and preventing pathological vascular remodeling. The current review mainly focuses on endogenous matrix proteins in blood vessels and discusses the interaction of these matrix proteins with other ECM proteins, cell surface receptors, cytokines, complement and coagulation factors, and their potential roles in maintaining vascular homeostasis and preventing pathological remodeling.
摘要：
ECM(细胞外基质)是调节血管稳态的血管微环境的主要成分。ECM蛋白包括胶原蛋白，弹性蛋白,非胶原糖蛋白，和蛋白聚糖/糖胺聚糖。ECM蛋白形成复杂的基质结构，如基底层、胶原蛋白和弹性蛋白纤维，通过直接相互作用或赖氨酰氧化酶介导的交联。此外，ECM蛋白直接与细胞表面受体或胞外分泌分子相互作用，发挥基质细胞和角质调节，分别。此外,细胞外蛋白酶降解或切割基质蛋白，从而促进ECM周转。这些相互作用构成了ECM相互作用网络，这对于维持血管稳态和防止病理性血管重塑至关重要。目前的综述主要集中在血管中的内源性基质蛋白，并讨论了这些基质蛋白与其他ECM蛋白的相互作用，细胞表面受体，细胞因子,补体和凝血因子，以及它们在维持血管稳态和预防病理性重塑中的潜在作用。
