METHODS: 103 patients (56 HCC, 47 HCA) with histopathologically proven hepatocellular lesions were the subjects of a cross-sectional investigation. A standardized imaging technique was used for DCE-MRI on all patients. Diffusion-weighted imaging (DWI) provided the ADC values. The diagnostic efficacy of DCE-MRI and ADC in differentiation was evaluated using statistical analyses, such as t-tests and receiver operating characteristic (ROC) curve analysis. SPSS VER 16 was used for the analysis of the collected data.
RESULTS: A total of 103 patients (female: male= 52:51, 57.14±3.09 years) were included in the study. The study revealed significant differences in DCE-MRI parameters and ADC values between HCC and HCA lesions. ADC value was significantly lower in HCC than in HCA (p < 0.001). The area under the curve (AUC) was 0.78 (95% CI: 0.69-0.87) for ADC, 0.84 (95% CI: 0.76-0.91) for Ktrans, and 0.72 (95% CI: 0.62-0.82) for Ve. Sensitivity and specificity for ADC were 76.59% and 71.42%, respectively. Also, PPV and NPV of ADC were 69.23% and 78.43%, respectively. Sensitivity and specificity for Ktrans were 82.14% and 76.59%, respectively. Also, PPV and NPV of Ktrans were 80.7% and 78.26%, respectively.
CONCLUSIONS: In conclusion, DCE-MRI-derived parameters, along with ADC values, exhibit promise as non-invasive tools for differentiating HCC from HCA.
方法:103例患者(56例HCC,47HCA),经组织病理学证实的肝细胞病变是横断面研究的对象。所有患者的DCE-MRI均采用标准化成像技术。扩散加权成像(DWI)提供ADC值。使用统计学分析评估DCE-MRI和ADC在分化中的诊断效能。如t检验和受试者工作特性(ROC)曲线分析。SPSSVER16用于分析收集的数据。
结果:共有103名患者(女性:男性=52:51,57.14±3.09岁)被纳入研究。该研究显示HCC和HCA病变之间的DCE-MRI参数和ADC值存在显着差异。HCC的ADC值明显低于HCA(p<0.001)。ADC的曲线下面积(AUC)为0.78(95%CI:0.69-0.87),Ktrans为0.84(95%CI:0.76-0.91),Ve为0.72(95%CI:0.62-0.82)。ADC的敏感性和特异性分别为76.59%和71.42%,分别。此外,ADC的PPV和NPV分别为69.23%和78.43%,分别。对Ktrans的敏感性和特异性分别为82.14%和76.59%,分别。此外,Ktrans的PPV和NPV分别为80.7%和78.26%,分别。
结论:结论:DCE-MRI衍生参数,连同ADC值,有望成为区分HCC和HCA的非侵入性工具。