PDF(Pubmed)
Abstract：
In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to the ones originating from bacteria. These organic substances are utilized in various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary metabolites are synthesized by utilizing intermediate compounds or by-products generated from the primary metabolic pathways. Secondary metabolites are not critical for the growth and development of an organism; however, they exhibit a variety of distinct biological characteristics. White-rot fungi are the only microorganisms able to decompose all wood components. Hence, they play an important role in both the carbon and nitrogen cycles by decomposing non-living organic substrates. They are ubiquitous in nature, particularly in hardwood (e.g., birch and aspen) forests. White-rot fungi, besides ligninolytic enzymes, produce different bioactive substances during their secondary metabolism including some compounds with antimicrobial and anticancer properties. Such properties could be of potential interest for the pharmaceutical industries. Considering the importance of the untapped biologically active secondary metabolites from white-rot fungi, the present paper reviews the secondary metabolites produced by white-rot fungi with different interesting bioactivities.
摘要：
近年来,与源自细菌的代谢产物相比，源自真菌的新型代谢产物的产量已大大增加。这些有机物质被用于各个领域，如农业，healthcare,和制药。因为所有分裂的活细胞都含有初级代谢物，次级代谢产物是通过利用初级代谢途径产生的中间化合物或副产物合成的。次级代谢物对生物体的生长和发育并不重要;然而,它们表现出各种不同的生物学特征。白腐真菌是唯一能够分解所有木材成分的微生物。因此，它们通过分解非生物有机底物，在碳和氮循环中起着重要作用。它们在自然界中无处不在，特别是硬木(例如，桦树和白杨）森林。白腐真菌,除了木质素分解酶,在其次级代谢过程中产生不同的生物活性物质，包括一些具有抗菌和抗癌特性的化合物。这种性质可能对制药工业有潜在的兴趣。考虑到来自白腐真菌的未开发的生物活性次级代谢产物的重要性，本文综述了白腐真菌产生的具有不同生物活性的次生代谢产物。
