PDF(Pubmed)
Abstract：
UNASSIGNED: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable indicator for assessing the risk of cardiovascular disease. However, the ability of non-HDL-C/apoB ratio to predict the risk of long-term mortality among the general population remains uncertain. The aim of this study is to explore the association of non-HDL-C/apoB ratio with long-term all-cause and cardiovascular mortality in adults of the United States.
UNASSIGNED: This retrospective cohort study was a further analysis of existing information from the National Health and Nutrition Examination Survey (NHANES). In the ultimate analysis, 12,697 participants from 2005 to 2014 were included. Kaplan-Meier (K-M) curves and the log-rank test were applied to visualize survival differences between groups. Multivariate Cox regression and restricted cubic spline (RCS) models were applied to evaluate the association of non-HDL-C/apoB ratio with all-cause and cardiovascular mortality. Subgroup analysis was conducted for the variables of age, sex, presence of coronary artery disease, diabetes and hypertriglyceridemia and usage of lipid-lowering drugs.
UNASSIGNED: The average age of the cohort was 46.8 ± 18.6 years, with 6215 (48.9%) participants being male. During a median follow-up lasting 68.0 months, 891 (7.0%) deaths were documented and 156 (1.2%) patients died of cardiovascular disease. Individuals who experienced all-cause and cardiovascular deaths had a lower non-HDL-C/apoB ratio compared with those without events (1.45 ± 0.16 vs. 1.50 ± 0.17 and 1.43 ± 0.17 vs. 1.50 ± 0.17, both P values < 0.001). The results of adjusted Cox regression models revealed that non-HDL-C/apoB ratio exhibited independent significance as a risk factor for both long-term all-cause mortality [hazard ratio (HR) = 0.51, 95% confidence interval (CI): 0.33-0.80] and cardiovascular mortality (HR = 0.33, 95% CI: 0.12-0.90). Additionally, a significant sex interaction was discovered (P for interaction <0.05), indicating a robust association between non-HDL-C/apoB ratio and long-term mortality among females. The RCS curve showed that non-HDL-C/apoB ratio had a negative linear association with long-term all-cause and cardiovascular mortality (P for non-linearity was 0.098 and 0.314).
UNASSIGNED: The non-HDL-C/apoB ratio may serve as a potential biomarker for predicting long-term mortality among the general population, independent of traditional risk factors.
UNASSIGNED: This retrospective cohort study was a further analysis of existing information from the National Health and Nutrition Examination Survey (NHANES). In the ultimate analysis, 12,697 participants from 2005 to 2014 were included. Kaplan-Meier (K-M) curves and the log-rank test were applied to visualize survival differences between groups. Multivariate Cox regression and restricted cubic spline (RCS) models were applied to evaluate the association of non-HDL-C/apoB ratio with all-cause and cardiovascular mortality. Subgroup analysis was conducted for the variables of age, sex, presence of coronary artery disease, diabetes and hypertriglyceridemia and usage of lipid-lowering drugs.
UNASSIGNED: The average age of the cohort was 46.8 ± 18.6 years, with 6215 (48.9%) participants being male. During a median follow-up lasting 68.0 months, 891 (7.0%) deaths were documented and 156 (1.2%) patients died of cardiovascular disease. Individuals who experienced all-cause and cardiovascular deaths had a lower non-HDL-C/apoB ratio compared with those without events (1.45 ± 0.16 vs. 1.50 ± 0.17 and 1.43 ± 0.17 vs. 1.50 ± 0.17, both P values < 0.001). The results of adjusted Cox regression models revealed that non-HDL-C/apoB ratio exhibited independent significance as a risk factor for both long-term all-cause mortality [hazard ratio (HR) = 0.51, 95% confidence interval (CI): 0.33-0.80] and cardiovascular mortality (HR = 0.33, 95% CI: 0.12-0.90). Additionally, a significant sex interaction was discovered (P for interaction <0.05), indicating a robust association between non-HDL-C/apoB ratio and long-term mortality among females. The RCS curve showed that non-HDL-C/apoB ratio had a negative linear association with long-term all-cause and cardiovascular mortality (P for non-linearity was 0.098 and 0.314).
UNASSIGNED: The non-HDL-C/apoB ratio may serve as a potential biomarker for predicting long-term mortality among the general population, independent of traditional risk factors.
摘要：
■一般来说，可以从非高密度脂蛋白胆固醇（non-HDL-C）浓度与载脂蛋白B（apoB）浓度之比推断胆固醇耗尽的脂质颗粒的鉴定，作为评估心血管疾病风险的可靠指标。然而,非HDL-C/apoB比值预测普通人群长期死亡风险的能力仍不确定.这项研究的目的是探讨非HDL-C/apoB比率与美国成年人长期全因死亡率和心血管死亡率的关系。
这项回顾性队列研究是对国家健康和营养调查（NHANES）现有信息的进一步分析。在最终分析中，包括2005年至2014年的12,697名参与者。应用Kaplan-Meier(K-M)曲线和对数秩检验来可视化组间生存差异。多变量Cox回归和限制性三次样条（RCS）模型用于评估非HDL-C/apoB比率与全因和心血管死亡率的相关性。对年龄变量进行亚组分析，性别,冠状动脉疾病的存在，糖尿病和高甘油三酯血症以及降脂药物的使用。
■该队列的平均年龄为46.8±18.6岁，6215名（48.9%）参与者为男性。在持续68.0个月的中位随访中，记录了891例（7.0％）死亡，156例（1.2％）患者死于心血管疾病。与没有事件的人相比，经历过全因死亡和心血管死亡的人的非HDL-C/apoB比率较低（1.45±0.16vs.1.50±0.17和1.43±0.17vs.1.50±0.17，两个P值均<0.001）。调整后的Cox回归模型结果显示，非HDL-C/apoB比率作为长期全因死亡率[风险比（HR）=0.51，95％置信区间（CI）：0.33-0.80]和心血管死亡率（HR=0.33，95％CI：0.12-0.90）的危险因素均具有独立意义。此外,发现了显著的性别相互作用(相互作用的P<0.05)，表明非HDL-C/apoB比值与女性长期死亡率之间存在密切关联。RCS曲线显示，non-HDL-C/apoB比值与长期全因死亡率和心血管死亡率呈负线性相关（非线性P分别为0.098和0.314）。
■non-HDL-C/apoB比值可作为预测普通人群长期死亡率的潜在生物标志物，独立于传统风险因素。
这项回顾性队列研究是对国家健康和营养调查（NHANES）现有信息的进一步分析。在最终分析中，包括2005年至2014年的12,697名参与者。应用Kaplan-Meier(K-M)曲线和对数秩检验来可视化组间生存差异。多变量Cox回归和限制性三次样条（RCS）模型用于评估非HDL-C/apoB比率与全因和心血管死亡率的相关性。对年龄变量进行亚组分析，性别,冠状动脉疾病的存在，糖尿病和高甘油三酯血症以及降脂药物的使用。
■该队列的平均年龄为46.8±18.6岁，6215名（48.9%）参与者为男性。在持续68.0个月的中位随访中，记录了891例（7.0％）死亡，156例（1.2％）患者死于心血管疾病。与没有事件的人相比，经历过全因死亡和心血管死亡的人的非HDL-C/apoB比率较低（1.45±0.16vs.1.50±0.17和1.43±0.17vs.1.50±0.17，两个P值均<0.001）。调整后的Cox回归模型结果显示，非HDL-C/apoB比率作为长期全因死亡率[风险比（HR）=0.51，95％置信区间（CI）：0.33-0.80]和心血管死亡率（HR=0.33，95％CI：0.12-0.90）的危险因素均具有独立意义。此外,发现了显著的性别相互作用(相互作用的P<0.05)，表明非HDL-C/apoB比值与女性长期死亡率之间存在密切关联。RCS曲线显示，non-HDL-C/apoB比值与长期全因死亡率和心血管死亡率呈负线性相关（非线性P分别为0.098和0.314）。
■non-HDL-C/apoB比值可作为预测普通人群长期死亡率的潜在生物标志物，独立于传统风险因素。
