PDF(Pubmed)
Abstract：
Previous studies have revealed the microbial metabolism of dietary choline in the gut, leading to its conversion into trimethylamine (TMA). Polymethoxyflavones (PMFs), exemplified by tangeretin, have shown efficacy in mitigating choline-induced cardiovascular inflammation. However, the specific mechanism by which these compounds exert their effects, particularly in modulating the gut microbiota, remains uncertain. This investigation focused on tangeretin, a representative PMFs, to explore its influence on the gut microbiota and the choline-TMA conversion process. Experimental results showed that tangeretin treatment significantly attenuated the population of CutC-active bacteria, particularly Clostridiaceae and Lactobacillus, induced by choline chloride in rat models. This inhibition led to a decreased efficiency in choline conversion to TMA, thereby ameliorating cardiovascular inflammation resulting from prolonged choline consumption. In conclusion, tangeretin\'s preventive effect against cardiovascular inflammation is intricately linked to its targeted modulation of TMA-producing bacterial activity.
摘要：
以前的研究已经揭示了肠道中膳食胆碱的微生物代谢，导致其转化为三甲胺（TMA）。多甲氧基黄酮（PMFs），以橘皮素为例，已显示出减轻胆碱诱导的心血管炎症的功效。然而,这些化合物发挥作用的具体机制，特别是在调节肠道微生物群方面，仍然不确定。这项调查的重点是橘皮素，一个代表性的PMFs，探讨其对肠道菌群和胆碱-TMA转化过程的影响。实验结果表明，橘皮素处理显著减弱了CutC活性细菌的种群，特别是梭菌科和乳酸菌，氯化胆碱诱导的大鼠模型。这种抑制作用导致胆碱转化为TMA的效率降低，从而改善因胆碱消耗延长而导致的心血管炎症。总之,橘皮素对心血管炎症的预防作用与其对产生TMA的细菌活性的靶向调节密切相关。
