PDF(Pubmed)
Abstract：
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (Allium sativum L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer.
摘要：
天然产品,特别是药用植物，由于其生物活性化合物，在对抗癌症和帮助发现和开发新的治疗剂方面至关重要。由于它们的低毒性，它们为开发有效的抗癌药物提供了有希望的途径，不同的化学结构，以及靶向各种癌症的能力。大蒜素是大蒜的主要成分之一。它是以前体状态保持在各种植物部分中的生物活性硫化合物。许多研究已经记录了这种天然化合物对许多慢性疾病的积极健康益处，包括胃,肝，乳房,肺，子宫颈,前列腺,还有结肠癌.此外，大蒜素可能针对影响癌症发展和扩散的几种癌症标志或基本生物学特征和功能。癌症的标志包括持续增殖，逃避生长抑制因子，转移,复制永生，血管生成,抵抗细胞死亡，改变了细胞能量学，和免疫逃避。本综述的发现应为研究人员和医学专业人员提供坚实的基础，以支持大蒜素作为前瞻性抗癌药物的基础和临床研究。这篇综述概述了大蒜素在癌症的每个标志中的抗癌作用。
