PDF(Pubmed)
Abstract：
The association between phytosterols and lipid levels remains poorly assessed at a population level. We assessed the associations between serum levels of six phytosterols (campesterol, campestanol, stigmasterol, sitosterol, sitostanol and brassicasterol) and of lipids [total, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipopoprotein A-IV and lipoprotein Lp(a)] in two cross-sectional surveys of a population-based, prospective study. Data from 910 participants (59.1% women, 70.4 ± 4.7 years) for the first survey (2009-2012) and from 721 participants (60.2% women, 75.1 ± 4.7 years) for the second survey (2014-2017) were used. After multivariable adjustment, all phytosterols were positively associated with total cholesterol: slope and (95% confidence interval) 1.594 (1.273-1.915); 0.073 (0.058-0.088); 0.060 (0.044-0.076); 2.333 (1.836-2.830); 0.049 (0.033-0.064) and 0.022 (0.017-0.028) for campesterol, campestanol, stigmasterol, sitosterol, sitostanol and brassicasterol, respectively, in the first survey, and 1.257 (0.965-1.548); 0.066 (0.052-0.079); 0.049 (0.034-0.063); 1.834 (1.382-2.285); 0.043 (0.029-0.057) and 0.018 (0.012-0.023) in the second survey, all p < 0.05. Similar positive associations were found between all phytosterols and LDL cholesterol. Positive associations were found between campesterol and sitosterol and HDL-cholesterol: slope and (95% CI) 0.269 (0.134-0.405) and 0.393 (0.184-0.602) for campesterol and sitosterol, respectively, in the first survey, and 1.301 (0.999-1.604) and 0.588 (0.327-0.849) in the second survey, all p < 0.05. No associations were found between phytosterols and triglyceride or lipoprotein Lp(a) levels, while a positive association between campesterol and apolipoprotein A-IV levels was found: 2.138 (0.454-3.822). Upon normal dietary intakes, serum phytosterol levels were positively associated with total and LDL cholesterol levels, while no consistent association with other lipid markers was found.
摘要：
植物甾醇和脂质水平之间的关联在种群水平上仍未得到很好的评估。我们评估了六种植物甾醇（菜油甾醇，campestanol,豆甾醇,谷甾醇,谷甾烷醇和油菜甾醇)和脂质[总计，低密度脂蛋白（LDL）-和高密度脂蛋白（HDL）-胆固醇，甘油三酯，载脂蛋白A-IV和脂蛋白Lp（a）]在两次基于人群的横断面调查中，前瞻性研究。数据来自910名参与者(59.1%为女性,70.4±4.7年），首次调查（2009-2012年）和721名参与者（60.2％的女性，第二次调查（2014-2017年）使用75.1±4.7年）。经过多变量调整后，所有植物甾醇均与总胆固醇呈正相关:菜油甾醇的斜率和(95%置信区间)1.594(1.273-1.915);0.073(0.058-0.088);0.060(0.044-0.076);2.333(1.836-2.830);0.049(0.033-0.064)和0.022(0.017-0.028),campestanol,豆甾醇,谷甾醇,谷甾烷醇和菜豆甾醇，分别,在第一次调查中，和1.257（0.965-1.548）；0.066（0.052-0.079）；0.049（0.034-0.063）；1.834（1.382-2.285）；0.043（0.029-0.057）和0.018（0.012-0.023），所有p<0.05。在所有植物甾醇和LDL胆固醇之间发现了类似的正相关性。发现菜油甾醇和谷甾醇与HDL-胆固醇之间存在正相关：菜油甾醇和谷甾醇的斜率和（95％CI）0.269（0.134-0.405）和0.393（0.184-0.602），分别,在第一次调查中，和第二次调查中的1.301（0.999-1.604）和0.588（0.327-0.849），所有p<0.05。植物甾醇与甘油三酯或脂蛋白Lp(a)水平之间没有发现关联，而菜油甾醇与载脂蛋白A-IV水平呈正相关：2.138（0.454-3.822）。在正常饮食摄入后，血清植物甾醇水平与总胆固醇和LDL胆固醇水平呈正相关，而未发现与其他脂质标志物的一致关联。
