PDF(Pubmed)
Abstract：
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.
摘要：
海洋细菌链霉菌属。HNS054有望成为生产天然产品的平台。从海洋海绵中分离出来，HNS054具有生物工程的几个理想特征：快速生长，耐盐性,以及与遗传工具的兼容性。它的基因组包含21个潜在的生物合成基因簇，提供丰富的天然产品来源。我们成功地设计了HNS054，使aborycin和actinorhodin的产量分别增加了4.5倍和1.2倍，分别,与S.coelicolorM1346同行相比。凭借其独特的功能和对遗传操作的适应性，HNS054成为开发新的海洋衍生药物和其他有价值的化合物的有希望的候选者。
