{Reference Type}: Journal Article
{Title}: Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054.
{Author}: Wang Q;Zhao J;Liu Z;Ding S;Huang Z;Chen J;
{Journal}: Int J Mol Sci
{Volume}: 25
{Issue}: 6
{Year}: 2024 Mar 8
{Factor}: 6.208
{DOI}: 10.3390/ijms25063127
{Abstract}: The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.