PDF(Pubmed)
Abstract：
Allergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic predisposition. While our comprehension of the pathophysiological engagement of immune and nonimmune cells in the conjunctiva has progressed, the same cannot be asserted for the cytokines mediating this inflammatory cascade. In this review, we proffer a comprehensive description of interleukins 4 (IL-4), IL-5, IL-6, IL-9, IL-13, IL-25, IL-31, and IL-33, as well as thymic stromal lymphopoietin (TSLP), elucidating their pathophysiological roles in mediating the allergic immune responses on the ocular surface. Delving into the nuanced functions of these cytokines holds promise for the exploration of innovative therapeutic modalities aimed at managing allergic conjunctivitis.
摘要：
过敏性结膜炎是影响眼部系统的常见免疫超敏反应性疾病之一。这种情况的临床表现表现出取决于环境因素的变异性，季节性动态，和遗传倾向。虽然我们对结膜中免疫和非免疫细胞的病理生理参与的理解已经取得了进展，对于介导这种炎症级联的细胞因子不能断言相同。在这次审查中,我们提供了白细胞介素4(IL-4)的全面描述，IL-5，IL-6，IL-9，IL-13，IL-25，IL-31和IL-33，以及胸腺基质淋巴细胞生成素（TSLP），阐明其在介导眼表过敏性免疫反应中的病理生理作用。深入研究这些细胞因子的细微差别功能，有望探索旨在管理过敏性结膜炎的创新治疗方式。
