PDF(Pubmed)
Abstract：
Nanotechnology-enabled pesticide delivery systems have been widely studied and show great prospects in modern agriculture. Nanodelivery systems not only achieve the controlled release of agrochemicals but also possess many unique characteristics. This study presents the development of a pH-responsive pesticide nanoformulation utilizing hollow mesoporous silica nanoparticles (HMSNs) as a nanocarrier. The nanocarrier was loaded with the photosensitive pesticide prochloraz (Pro) and then combined with ZnO quantum dots (ZnO QDs) through electrostatic interactions. ZnO QDs serve as both the pH-responsive gatekeeper and the enhancer of the pesticide. The results demonstrate that the prepared nanopesticide exhibits high loading efficiency (24.96%) for Pro. Compared with Pro technical, the degradation rate of Pro loaded in HMSNs@Pro@ZnO QDs was reduced by 26.4% after 24 h ultraviolet (UV) exposure, indicating clearly improved photostability. In a weak acidic environment (pH 5.0), the accumulated release of the nanopesticide after 48 h was 2.67-fold higher than that in a neutral environment. This indicates the excellent pH-responsive characteristic of the nanopesticide. The tracking experiments revealed that HMSNs can be absorbed by rice leaves and subsequently transported to other tissues, indicating their potential for effective systemic distribution and targeted delivery. Furthermore, the bioactivity assays confirmed the fungicidal efficacy of the nanopesticide against rice blast disease. Therefore, the constructed nanopesticide holds great prospect in nanoenabled agriculture, offering a novel strategy to enhance pesticide utilization.
摘要：
纳米技术支持的农药递送系统已被广泛研究，并在现代农业中显示出巨大的前景。纳米递送系统不仅实现了农用化学品的控制释放，而且具有许多独特的特性。这项研究提出了利用中空介孔二氧化硅纳米颗粒（HMSNs）作为纳米载体的pH响应型农药纳米制剂的开发。纳米载体负载有光敏农药丙草胺(Pro),然后通过静电相互作用与ZnO量子点(ZnO量子点)结合。ZnOQD既是pH响应性的看门人，也是农药的增强剂。结果表明，所制备的纳米农药对Pro具有较高的负载效率（24.96％）。与Pro技术相比，负载在HMSNs@Pro@ZnOQDs中的Pro在24h紫外线（UV）暴露后降解率降低了26.4%，表明明显改进的光稳定性。在弱酸性环境（pH5.0）中，48小时后纳米农药的累积释放量比中性环境高2.67倍。这表明纳米农药具有优异的pH响应特性。跟踪实验表明，HMSN可以被水稻叶片吸收，然后运输到其他组织，表明它们有效的全身分布和有针对性的递送的潜力。此外，生物活性试验证实了纳米农药对稻瘟病的杀菌效力。因此,构建的纳米农药在纳米农业中具有广阔的前景，提供了一种提高农药利用率的新策略。
