PDF(Pubmed)
Abstract：
Minimally invasive oxygen-ozone (O2-O3) therapy utilizing the biochemical effects of O2-O3 mixture is commonly used in the treatment of musculoskeletal pain. The literature dealing with O2-O3 therapy of spinal pain focuses mainly on the lumbosacral region. The aim of this review is to evaluate the efficacy of O2-O3 therapy in musculoskeletal pain in the neck region. The Medline (PubMed), SCOPUS, Web of Science, and Google Scholar databases were searched for clinical studies, using the free text terms: ozone, neck, cervical, spine, pain, disc, hernia, nucleolysis, paravertebral, treatment, and various combinations of them. In total, seven studies (two randomized controlled trials and five observational studies) were found. These studies dealt with the intradiscal or intramuscular paravertebral application of O2-O3 mixture in patients with myofascial pain syndrome, cervical disc hernias, and chronic neck pain. All these studies proved a significant decrease in neck pain (evaluated by Visual Analog Scale or Numerical Rating Scale), and most of them showed improvement in functional status (measured by Oswestry Disability Index or Neck Disability Index). In addition, other pain assessment scales and function and quality of life measures (DN4 questionnaire, pain pressure threshold, cervical lateral flexion range of motion, Japanese Orthopedic Association scale, 12- and 36-Item Short Form Surveys, modified MacNab criteria, and analgesic drug intake reduction) were used. Changes in these measurements also mostly supported the efficacy of O2-O3 treatment. No significant complications of the treatment were reported. The available evidence is sparse, but despite this, the O2-O3 treatment of musculoskeletal neck pain can be considered potentially beneficial and relatively safe.
摘要：
利用O2-O3混合物的生化作用的微创氧气-臭氧（O2-O3）疗法通常用于治疗肌肉骨骼疼痛。有关O2-O3治疗脊柱疼痛的文献主要集中在腰s区。这篇综述的目的是评估O2-O3治疗颈部肌肉骨骼疼痛的疗效。TheMedline(PubMed),Scopus,WebofScience,搜索谷歌学者数据库进行临床研究，使用自由文本术语：臭氧，脖子,子宫颈,脊柱,疼痛,光盘,疝气,成核,椎旁,治疗,以及它们的各种组合。总的来说,共发现7项研究(2项随机对照试验和5项观察性研究).这些研究涉及肌筋膜疼痛综合征患者的椎间盘内或椎旁肌内应用O2-O3混合物，颈椎间盘突出症,和慢性颈部疼痛。所有这些研究都证明了颈部疼痛的显着减少（通过视觉模拟量表或数值评定量表进行评估），他们中的大多数表现出功能状态的改善（通过Oswestry残疾指数或颈部残疾指数衡量）。此外,其他疼痛评估量表和功能和生活质量测量(DN4问卷，疼痛压力阈值，颈椎侧屈活动范围，日本骨科协会量表，12项和36项简短表格调查，修改后的MacNab标准，和镇痛药物摄入量减少）。这些测量的变化也主要支持O2-O3治疗的功效。治疗无明显并发症。现有的证据很少,但尽管如此,O2-O3治疗肌肉骨骼颈部疼痛可被认为是潜在有益且相对安全的.
