PDF(Pubmed)
Abstract：
Lipid rafts, specialised microdomains within cell membranes, play a central role in orchestrating various aspects of neurodevelopment, ranging from neural differentiation to the formation of functional neuronal networks. This review focuses on the multifaceted involvement of lipid rafts in key neurodevelopmental processes, including neural differentiation, synaptogenesis and myelination. Through the spatial organisation of signalling components, lipid rafts facilitate precise signalling events that determine neural fate during embryonic development and in adulthood. The evolutionary conservation of lipid rafts underscores their fundamental importance for the structural and functional complexity of the nervous system in all species. Furthermore, there is increasing evidence that environmental factors can modulate the composition and function of lipid rafts and influence neurodevelopmental processes. Understanding the intricate interplay between lipid rafts and neurodevelopment not only sheds light on the fundamental mechanisms governing brain development but also has implications for therapeutic strategies aimed at cultivating neuronal networks and addressing neurodevelopmental disorders.
摘要：
脂筏,细胞膜内的特殊微域，在协调神经发育的各个方面发挥核心作用，从神经分化到功能性神经元网络的形成。这篇综述侧重于脂质筏在关键神经发育过程中的多方面参与，包括神经分化，突触形成和髓鞘形成。通过信号组件的空间组织，脂筏促进了精确的信号事件，这些信号事件决定了胚胎发育和成年期的神经命运。脂筏的进化保守性强调了它们对所有物种神经系统的结构和功能复杂性的根本重要性。此外，越来越多的证据表明，环境因素可以调节脂筏的组成和功能，并影响神经发育过程。了解脂筏与神经发育之间的复杂相互作用不仅可以阐明控制大脑发育的基本机制，而且还可以对旨在培养神经元网络和解决神经发育障碍的治疗策略产生影响。
