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Abstract：
Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with diverse structural motifs and various biological properties. With the continuous improvement and extensive application of bioinformatic tools (e.g., anti-SMASH, NCBI, UniProt), more and more biosynthetic gene clusters (BGCs) of secondary metabolites (SMs) have been identified in Fusarium strains. However, the biosynthetic logics of these SMs have not yet been well investigated till now. With the aim to increase our knowledge of the biosynthetic logics of NPRS-encoding products in Fusarium, this review firstly provides an overview of research advances in elucidating their biosynthetic pathways.
摘要：
真菌非核糖体肽合成酶（NRPS）编码产物在新药发现中起着至关重要的作用。镰刀菌,最常见的丝状真菌之一，以其具有不同结构基序和各种生物学特性的NRPS型化合物的生物合成潜力而闻名。随着生物信息学工具的不断改进和广泛应用(例如，反SMASH,NCBI,UniProt)，越来越多的次生代谢产物(SMs)生物合成基因簇(BGCs)在镰刀菌菌株中被鉴定出来。然而,迄今为止，这些SM的生物合成逻辑尚未得到很好的研究。为了增加我们对镰刀菌NPRS编码产品的生物合成逻辑的了解，本文首先概述了其生物合成途径的研究进展。
