Abstract：
Previous studies have shown associations between children\'s exposure to phthalates and neurodevelopmental disorders. Whereas the impact of exposure to phthalate alternatives is understudied. This study aimed to evaluate the association of exposure to phthalates/their alternatives with the risk of dyslexia. We recruited 745 children (355 dyslexia and 390 non-dyslexia) via the Tongji Reading Environment and Dyslexia Research Project, and their urine samples were collected. A total of 26 metabolites of phthalates/their alternatives were measured. Multivariate logistic regression and quantile-based g-computation were used to estimate the associations of exposure to the phthalates/their alternatives with dyslexia. More than 80% of the children had 17 related metabolites detected in their urine samples. After adjustment, the association between mono-2-(propyl-6-hydroxy-heptyl) phthalate (OH-MPHP) with the risk of dyslexia was observed. Compared with the lowest quartile of OH-MPHP levels, the odds of dyslexia for the third quartile was 1.93 (95% CI 1.06, 3.57). Regarding mixture analyses, it was found that OH-MPHP contributed the most to the association. Further analyses stratified by sex revealed that this association was only observed in boys. Our results suggested a significantly adverse association of di-2-propylheptyl phthalate exposure with children\'s language abilities. It highlights the necessity to prioritize the protection of children\'s neurodevelopment by minimizing their exposure to endocrine-disrupting chemicals like di-2-propylheptyl phthalate.
摘要：
以前的研究表明，儿童接触邻苯二甲酸盐与神经发育障碍之间存在关联。而接触邻苯二甲酸酯替代品的影响研究不足。这项研究旨在评估接触邻苯二甲酸盐/其替代品与阅读障碍风险的关系。我们通过同济阅读环境和阅读障碍研究项目招募了745名儿童（355名阅读障碍和390名非阅读障碍），并收集了他们的尿样。总共测量了26种邻苯二甲酸酯/其替代品的代谢物。使用多变量逻辑回归和基于分位数的g计算来估计暴露于邻苯二甲酸酯/其替代品与阅读障碍的关联。超过80％的儿童在尿液样本中检测到17种相关代谢物。调整后,观察到邻苯二甲酸单-2-(丙基-6-羟基-庚基)酯(OH-MPHP)与阅读障碍风险的相关性.与OH-MPHP水平的最低四分位数相比，第三四分位数的阅读障碍几率为1.93(95%CI1.06,3.57).关于混合物分析，发现OH-MPHP对这种关联的贡献最大。按性别分层的进一步分析表明，这种关联仅在男孩中观察到。我们的结果表明邻苯二甲酸二-2-丙基庚酯暴露与儿童的语言能力存在显著的不良关联。它强调必须优先保护儿童的神经发育，尽量减少他们接触内分泌干扰化学物质，如邻苯二甲酸二-2-丙基庚酯。
