Abstract：
Staphylococci are responsible for many infections in humans, starting with skin and soft tissue infections and finishing with invasive diseases such as endocarditis, sepsis and pneumonia, which lead to high mortality. Patients with sepsis often demonstrate activated clotting pathways, decreased levels of anticoagulants, decreased fibrinolysis, activated endothelial surfaces and activated platelets. This results in disseminated intravascular coagulation and formation of a microthrombus, which can lead to a multiorgan failure. This review describes various staphylococcal virulence factors that contribute to vascular thrombosis, including deep vein thrombosis in infected patients. The article presents mechanisms of action of different factors released by bacteria in various host defense lines, which in turn can lead to formation of blood clots in the vessels.
摘要：
葡萄球菌是人类许多感染的原因，从皮肤和软组织感染开始，到心内膜炎等侵入性疾病结束，脓毒症和肺炎,导致高死亡率。败血症患者通常表现出活化的凝血途径，抗凝剂水平下降，纤维蛋白溶解减少，活化的内皮表面和活化的血小板。这导致弥散性血管内凝血和微血栓的形成，会导致多器官衰竭.这篇综述描述了导致血管血栓形成的各种葡萄球菌毒力因子。包括感染患者的深静脉血栓形成。本文介绍了细菌在各种宿主防线中释放的不同因子的作用机制。这反过来会导致血管中血凝块的形成。
