Abstract：
OBJECTIVE: To compare anterior chamber angle (ACA) parameters measured by Anterior Segment Optical Coherence Tomography (ASOCT) and biometric parameters measured by Swept-Source (SS) OCT-based biometry among patients with suspected occludable angles and open angles.
METHODS: An analytical, cross-sectional study was performed on subjects attending our ophthalmology outpatient department with suspected occludable angles (van Herick grades 0, 1, and 2) in group 1, and with open angles (van Herick grades 3 and 4) in group 2. Each subject underwent a complete ophthalmic examination to exclude any intraocular pathology like cataract. We recruited 128 eyes of 64 subjects, 34 in group 1 and 30 in group 2. Each eye was henceforth subjected to ASOCT (Spectralis, Heidelberg Engineering, Heidelberg) and SS-OCT-based optical biometry (IOL Master 700, Carl Zeiss Meditec AG). Anatomical parameters were recorded and compared between the two groups.
RESULTS: The main outcome measures of the study included nine ASOCT parameters (central corneal thickness [CCT], lens vault, AOD750, ACA, TISA750 [nasal and temporal], and ACW) and five optical biometric parameters (CCT, ACD, WTW, LT, and axial length). We found a significant difference (p < 0.05) among all the anatomical parameters between the two groups, except CCT which was not significantly different (p = 0.297).
CONCLUSIONS: ASOCT and SSOCT biometry overcome the challenges of gonioscopy and allow screening for angle closure disease in otherwise normal subjects. ASOCT may serve as an alternative to gonioscopy as it clearly separates occludable angles from open angles in a non-invasive and objective manner.
METHODS: An analytical, cross-sectional study was performed on subjects attending our ophthalmology outpatient department with suspected occludable angles (van Herick grades 0, 1, and 2) in group 1, and with open angles (van Herick grades 3 and 4) in group 2. Each subject underwent a complete ophthalmic examination to exclude any intraocular pathology like cataract. We recruited 128 eyes of 64 subjects, 34 in group 1 and 30 in group 2. Each eye was henceforth subjected to ASOCT (Spectralis, Heidelberg Engineering, Heidelberg) and SS-OCT-based optical biometry (IOL Master 700, Carl Zeiss Meditec AG). Anatomical parameters were recorded and compared between the two groups.
RESULTS: The main outcome measures of the study included nine ASOCT parameters (central corneal thickness [CCT], lens vault, AOD750, ACA, TISA750 [nasal and temporal], and ACW) and five optical biometric parameters (CCT, ACD, WTW, LT, and axial length). We found a significant difference (p < 0.05) among all the anatomical parameters between the two groups, except CCT which was not significantly different (p = 0.297).
CONCLUSIONS: ASOCT and SSOCT biometry overcome the challenges of gonioscopy and allow screening for angle closure disease in otherwise normal subjects. ASOCT may serve as an alternative to gonioscopy as it clearly separates occludable angles from open angles in a non-invasive and objective manner.
摘要：
目的：比较前房角（ACA）参数测量的前房角（ACA）和基于扫描源（SS）OCT的生物测量测量的生物参数在怀疑有闭塞角和开放角的患者之间。
方法：分析，我们对眼科门诊部就诊的受试者进行了横断面研究,其中第1组有疑似可闭合角度(vanHerick等级0,1和2级),第2组有开放角度(vanHerick等级3和4级).每位受试者都进行了完整的眼科检查，以排除任何眼内病理，例如白内障。我们招募了64名受试者的128只眼睛，第1组34和第2组30。此后每只眼睛都要接受ASOCT(光谱，海德堡工程,海德堡）和基于SS-OCT的光学生物测定（IOLMaster700，CarlZeissMeditecAG）。记录并比较两组患者的解剖学参数。
结果：该研究的主要结局指标包括9个ASOCT参数（中央角膜厚度[CCT]，镜头拱顶,AOD750,ACA,TISA750[鼻部和颞部]，和ACW)和五个光学生物特征参数(CCT，ACD,WTW,LT,和轴向长度）。我们发现两组之间的所有解剖参数之间存在显着差异（p<0.05），除了CCT没有显着差异（p=0.297）。
结论：ASOCT和SSOCT生物测量克服了房角镜检查的挑战，允许在其他正常受试者中筛查闭角疾病。ASOCT可以作为角度镜检查的替代方案，因为它可以以非侵入性和客观的方式清楚地将可遮挡角度与打开角度分开。
方法：分析，我们对眼科门诊部就诊的受试者进行了横断面研究,其中第1组有疑似可闭合角度(vanHerick等级0,1和2级),第2组有开放角度(vanHerick等级3和4级).每位受试者都进行了完整的眼科检查，以排除任何眼内病理，例如白内障。我们招募了64名受试者的128只眼睛，第1组34和第2组30。此后每只眼睛都要接受ASOCT(光谱，海德堡工程,海德堡）和基于SS-OCT的光学生物测定（IOLMaster700，CarlZeissMeditecAG）。记录并比较两组患者的解剖学参数。
结果：该研究的主要结局指标包括9个ASOCT参数（中央角膜厚度[CCT]，镜头拱顶,AOD750,ACA,TISA750[鼻部和颞部]，和ACW)和五个光学生物特征参数(CCT，ACD,WTW,LT,和轴向长度）。我们发现两组之间的所有解剖参数之间存在显着差异（p<0.05），除了CCT没有显着差异（p=0.297）。
结论：ASOCT和SSOCT生物测量克服了房角镜检查的挑战，允许在其他正常受试者中筛查闭角疾病。ASOCT可以作为角度镜检查的替代方案，因为它可以以非侵入性和客观的方式清楚地将可遮挡角度与打开角度分开。
