PDF(Pubmed)
Abstract：
An epizootic of rift valley fever (RVF) was suspected on 21 February 2021 in various districts of Madagascar, with a lab confirmation on 1 April 2021. A cross-sectional survey aiming to detect cases of RVF in humans and to study the circulation of rift valley fever virus (RVFV) in animals was conducted from 22 April to 4 May 2021 in the district of Mananjary. Blood samples from cattle and humans were tested using serological and molecular techniques. In cattle, the circulation of RVFV was confirmed between 5 February and 4 May 2021. The positivity rates of anti-RVFV IgG and IgM were 60% and 40%, respectively. In humans, the circulation of RVFV was observed from 1 April to 5 May 2021. The positivity rate of RVFV was estimated to be 11.7% by combining the results of the molecular and serological approaches. Of the 103 individuals who agreed to participate in the survey, 3 were determined to be positive by RT-PCR, and 10 had anti-RVFV IgM. Among them, one was positive for both. Given that previous studies have reported the circulation of RVFV during inter-epidemic periods and the occurrence of outbreaks due to imported RVFV in Madagascar, our findings suggest the importance of strengthening RVF surveillance from a \"One Health\" perspective by conducting syndromic and risk-based surveillance at the national and regional levels.
摘要：
2021年2月21日，马达加斯加各个地区怀疑发生了裂谷热（RVF）流行病，2021年4月1日实验室确认。2021年4月22日至5月4日，在Mananjary地区进行了一项横断面调查，旨在检测人类中的RVF病例并研究动物中裂谷热病毒（RVFV）的传播。使用血清学和分子技术测试了来自牛和人类的血液样品。在牛身上,在2021年2月5日至5月4日期间确认了RVFV的流通。抗RVFVIgG和IgM阳性率分别为60%和40%,分别。在人类中,从2021年4月1日至5月5日观察到RVFV的循环。通过结合分子和血清学方法的结果，RVFV的阳性率估计为11.7％。在同意参与调查的103个人中，3例通过RT-PCR确定为阳性，10例有抗RVFVIgM。其中,一个对两者都是积极的。鉴于先前的研究报告了在疫情期间RVFV的流通以及马达加斯加因进口RVFV而爆发的疫情，我们的研究结果表明,从"一个健康"的角度,通过在国家和地区层面开展综合征和基于风险的监测,加强裂谷热监测的重要性.
