PDF(Pubmed)
Abstract：
Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. According to PRISMA guidelines, a systematic literature search was performed up to 6 January 2024. Clinical studies using ozone to treat caries of deciduous teeth were considered for inclusion. Out of the 215 records retrieved, seven studies were eventually included in the review, all of which used gaseous ozone. Four studies were judged at high risk of bias, two at low risk, and one of some concerns. The great heterogeneity of designs, outcomes, and protocols made it impossible to conduct a meta-analysis. Despite some limitations, the evidence yielded by the included studies suggests that ozone application, regardless of the protocol applied, is comparable to other interventions in terms of clinical outcomes and anti-bacterial activity, with no reported adverse effects and good patient acceptance. Therefore, ozone application may be a non-invasive approach to treat caries in primary dentition, especially in very young and poorly cooperative patients. Further standardized and rigorous studies are, however, needed to identify the best clinical protocols for this specific field.
摘要：
儿童龋齿是一种常见且使人衰弱的疾病，他们的管理往往具有挑战性。这项系统评价的目的是研究臭氧应用于治疗原发性牙列龋齿的有效性。根据PRISMA指南,截至2024年1月6日,我们进行了系统的文献检索.考虑纳入使用臭氧治疗乳牙龋齿的临床研究。在检索到的215条记录中，七项研究最终被纳入审查，所有这些都使用了气态臭氧。四项研究被判断为偏倚的高风险，两个风险低的人，也是一些担忧之一。设计的巨大异质性，结果，和协议使得无法进行荟萃分析。尽管有一些限制,纳入研究的证据表明，臭氧的应用，不管采用什么协议，在临床结果和抗菌活性方面与其他干预措施相当，没有报告的不良反应和良好的患者接受度。因此,臭氧的应用可能是一种非侵入性的方法来治疗龋齿在原牙列，特别是在非常年轻和合作不良的患者中。进一步规范和严格的研究，然而,需要确定该特定领域的最佳临床方案。
