PDF(Pubmed)
Abstract：
Wound healing is an intricate and fine regulatory process. In diabetic patients, advanced glycation end products (AGEs), excessive reactive oxygen species (ROS), biofilm formation, persistent inflammation, and angiogenesis regression contribute to delayed wound healing. Epigenetics, the fast-moving science in the 21st century, has been up to date and associated with diabetic wound repair. In this review, we go over the functions of epigenetics in diabetic wound repair in retrospect, covering transcriptional and posttranscriptional regulation. Among these, we found that histone modification is widely involved in inflammation and angiogenesis by affecting macrophages and endothelial cells. DNA methylation is involved in factors regulation in wound repair but also affects the differentiation phenotype of cells in hyperglycemia. In addition, noncodingRNA regulation and RNA modification in diabetic wound repair were also generalized. The future prospects for epigenetic applications are discussed in the end. In conclusion, the study suggests that epigenetics is an integral regulatory mechanism in diabetic wound healing.
摘要：
伤口愈合是一个复杂而精细的调节过程。在糖尿病患者中，糖基化终产物（AGEs），过量的活性氧（ROS），生物膜的形成，持续性炎症,和血管生成的消退有助于延迟的伤口愈合。表观遗传学,21世纪快速发展的科学，是最新的，与糖尿病伤口修复有关。在这次审查中,我们回顾了表观遗传学在糖尿病伤口修复中的作用，涵盖转录和转录后调控。其中,我们发现组蛋白修饰通过影响巨噬细胞和内皮细胞而广泛参与炎症和血管生成。DNA甲基化参与创伤修复中的因子调节,但也影响高血糖细胞的分化表型。此外,noncodingRNA调节和RNA修饰在糖尿病伤口修复中也得到了推广。最后讨论了表观遗传学应用的未来前景。总之,这项研究表明，表观遗传学是糖尿病伤口愈合过程中不可或缺的调节机制。
