PDF(Pubmed)
Abstract：
UNASSIGNED: Cushing\'s syndrome (CS) during pregnancy is a rare endocrine disorder characterized by hypercortisolism, which is significantly associated with maternal-fetal complications. Despite its rarity, CS during pregnancy may be related to a high risk of complications for both the mother and fetus.The aim of the present case study is to update the diagnostic approach to CS during pregnancy and the therapeutic strategies for this medical condition to minimize maternal-fetal complications.
UNASSIGNED: Here, we present two cases of CS in pregnant women, one of whom had twins. Typical clinical symptoms and signs of hypercortisolism developed at the beginning of pregnancy. The plasma cortisol diurnal rhythm of the pregnant patient was absent. CS was confirmed by cortisol and adrenocorticotropic hormone (ACTH) assessment, as well as imaging examination. We investigated the changes in the hypothalamic-pituitary-adrenal axis during normal pregnancy and the etiology, diagnosis and treatment of CS during pregnancy.
UNASSIGNED: Due to the associated risks of laparoscopic adrenalectomy,it is uncertain whether this treatment significantly decreases overall maternal mortality. Additional observational research and validation through randomized controlled trials (RCTs) are required. We advise that CS in pregnant women be diagnosed and treated by experienced teams in relevant departments and medical centers.
UNASSIGNED: Here, we present two cases of CS in pregnant women, one of whom had twins. Typical clinical symptoms and signs of hypercortisolism developed at the beginning of pregnancy. The plasma cortisol diurnal rhythm of the pregnant patient was absent. CS was confirmed by cortisol and adrenocorticotropic hormone (ACTH) assessment, as well as imaging examination. We investigated the changes in the hypothalamic-pituitary-adrenal axis during normal pregnancy and the etiology, diagnosis and treatment of CS during pregnancy.
UNASSIGNED: Due to the associated risks of laparoscopic adrenalectomy,it is uncertain whether this treatment significantly decreases overall maternal mortality. Additional observational research and validation through randomized controlled trials (RCTs) are required. We advise that CS in pregnant women be diagnosed and treated by experienced teams in relevant departments and medical centers.
摘要：
■怀孕期间库欣综合征（CS）是一种罕见的内分泌紊乱，其特征是皮质醇增多症，这与母胎并发症显著相关。尽管它很罕见,怀孕期间的CS可能与母亲和胎儿并发症的高风险有关。本案例研究的目的是更新妊娠期间CS的诊断方法以及针对这种医学状况的治疗策略，以最大程度地减少母胎并发症。
■这里，我们介绍了两例孕妇的CS，其中一个有双胞胎。典型的临床症状和皮质醇增多症的体征在怀孕开始时出现。孕妇的血浆皮质醇昼夜节律缺失。CS通过皮质醇和促肾上腺皮质激素（ACTH）评估得到证实，以及影像学检查。我们调查了正常妊娠期间下丘脑-垂体-肾上腺轴的变化和病因，妊娠期间CS的诊断和治疗。
■由于腹腔镜肾上腺切除术的相关风险，目前尚不清楚这种治疗方法是否能显著降低产妇总死亡率.需要通过随机对照试验（RCT）进行其他观察性研究和验证。我们建议由相关部门和医疗中心的经验丰富的团队来诊断和治疗孕妇的CS。
■这里，我们介绍了两例孕妇的CS，其中一个有双胞胎。典型的临床症状和皮质醇增多症的体征在怀孕开始时出现。孕妇的血浆皮质醇昼夜节律缺失。CS通过皮质醇和促肾上腺皮质激素（ACTH）评估得到证实，以及影像学检查。我们调查了正常妊娠期间下丘脑-垂体-肾上腺轴的变化和病因，妊娠期间CS的诊断和治疗。
■由于腹腔镜肾上腺切除术的相关风险，目前尚不清楚这种治疗方法是否能显著降低产妇总死亡率.需要通过随机对照试验（RCT）进行其他观察性研究和验证。我们建议由相关部门和医疗中心的经验丰富的团队来诊断和治疗孕妇的CS。
