关键词: ADAR RNA editing dsRNA innate immunity inosine

Mesh : RNA / genetics Adenosine Deaminase / genetics metabolism RNA Editing RNA-Binding Proteins / genetics metabolism Inosine / metabolism RNA, Double-Stranded

来  源:   DOI:10.1261/rna.079990.124   PDF(Pubmed)

Abstract:
In this article, I recount my memories of key experiments that led to my entry into the RNA editing/modification field. I highlight initial observations made by the pioneers in the ADAR field, and how they fit into our current understanding of this family of enzymes. I discuss early mysteries that have now been solved, as well as those that still linger. Finally, I discuss important, outstanding questions and acknowledge my hope for the future of the RNA editing/modification field.
摘要:
在本文中,我讲述了我对导致我进入RNA编辑/修饰领域的关键实验的记忆。我强调了ADAR领域先驱们的初步观察,以及它们如何适应我们目前对这个酶家族的理解。我讨论了现在已经解决的早期谜团,以及那些仍然徘徊的人。最后,我讨论重要的事情,突出的问题,并承认我对RNA编辑/修饰领域的未来的希望。
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