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Abstract：
BACKGROUND: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast. Research on combined use of IVIM and ASL MRI in patients with AKI is rare. This study aims to investigate the MRI characteristics of IVIM and ASL in patients with tubulointerstitial nephritis (TIN) and to explore their relationship with pathological findings and renal recovery.
METHODS: Single-centre, prospective, observational cohort study of 30 patients with biopsy-proven TIN. Participants will undergo renal IVIM and ASL MRI within 7 days post-biopsy. The pathological assessments of active and chronic tubulointerstitial injuries will be semiscored using modified Banff criteria. The estimated glomerular filtration rate (eGFR) during follow-up and prevalence of chronic kidney disease at 3 and 6 months will be reported. An eGFR below 45 mL/min is considered a poor renal outcome.
BACKGROUND: The study has been reviewed and approved by the Ethics Committee of Peking University First Hospital and written informed consent will be obtained from all participants (2022Y503). The study results will be disseminated through publication in a relevant peer-reviewed journal and presentation at academic meetings to increase awareness and share findings with the scientific community.
METHODS: Single-centre, prospective, observational cohort study of 30 patients with biopsy-proven TIN. Participants will undergo renal IVIM and ASL MRI within 7 days post-biopsy. The pathological assessments of active and chronic tubulointerstitial injuries will be semiscored using modified Banff criteria. The estimated glomerular filtration rate (eGFR) during follow-up and prevalence of chronic kidney disease at 3 and 6 months will be reported. An eGFR below 45 mL/min is considered a poor renal outcome.
BACKGROUND: The study has been reviewed and approved by the Ethics Committee of Peking University First Hospital and written informed consent will be obtained from all participants (2022Y503). The study results will be disseminated through publication in a relevant peer-reviewed journal and presentation at academic meetings to increase awareness and share findings with the scientific community.
摘要：
背景：急性肾损伤（AKI）是一种病因复杂且结局不同的危重症，血液动力学功能障碍的地方，肾脏灌注不足和炎症是其发展和进展的关键因素。早期和准确的诊断对于启动靶向治疗如液体复苏至关重要，血管活性剂或类固醇治疗，这对于改善患者预后至关重要。体素内不相干运动（IVIM）MRI评估毛细血管灌注和组织水扩散，而动脉自旋标记（ASL）MRI无需对比即可测量肾血流量。关于AKI患者联合运用IVIM和ASLMRI的研讨较为罕见。本研究旨在探讨肾小管间质性肾炎（TIN）患者IVIM和ASL的MRI特征，并探讨其与病理结果和肾脏恢复的关系。
方法：单中心，prospective,30例经活检证实的TIN患者的观察性队列研究。参与者将在活检后7天内接受肾脏IVIM和ASLMRI。将使用改良的班夫标准对活动性和慢性肾小管间质损伤的病理学评估进行半核。将报告随访期间估计的肾小球滤过率（eGFR）以及3个月和6个月时慢性肾病的患病率。低于45mL/min的eGFR被认为是不良的肾脏结果。
背景：该研究已获得北京大学第一医院伦理委员会的审查和批准，并将获得所有参与者的书面知情同意书（2022Y503）。研究结果将通过发表在相关的同行评审期刊上并在学术会议上发表来传播，以提高认识并与科学界分享发现。
方法：单中心，prospective,30例经活检证实的TIN患者的观察性队列研究。参与者将在活检后7天内接受肾脏IVIM和ASLMRI。将使用改良的班夫标准对活动性和慢性肾小管间质损伤的病理学评估进行半核。将报告随访期间估计的肾小球滤过率（eGFR）以及3个月和6个月时慢性肾病的患病率。低于45mL/min的eGFR被认为是不良的肾脏结果。
背景：该研究已获得北京大学第一医院伦理委员会的审查和批准，并将获得所有参与者的书面知情同意书（2022Y503）。研究结果将通过发表在相关的同行评审期刊上并在学术会议上发表来传播，以提高认识并与科学界分享发现。
