PDF(Pubmed)
Abstract：
OBJECTIVE: To assess respiratory symptoms and nocturnal gastro-oesophageal reflux (nGER) among untreated obstructive sleep apnoea (OSA) patients, compared with the general population. Also, if nGER associates differently with respiratory symptoms among OSA patients.
METHODS: 2 study cohorts were included: 822 newly diagnosed subjects with moderate-severe OSA and 738 Icelandic general population study participants. All participants answered the same questionnaires. Those reporting nGER symptoms at least once per week were defined as \'with nGER\'; those without nGER symptoms and without nGER medication were defined as \'no nGER\'; and other participants were defined as having \'possible nGER\'. Propensity score-based weights were used to minimise confounding and selection bias and facilitate causal interpretations.
RESULTS: The prevalence of nGER among OSA patients was 14.1%, compared with 5.8% in the general population. This increased prevalence in OSA was not explained by differences in age, gender, body mass index, smoking, hypertension and diabetes (adjusted OR (95% CI)=3.79 (2.24 to 6.43)). OSA patients \'with nGER\' and with \'possible nGER\' reported more wheezing (44% and 44% vs 25%, respectively) and productive cough (47% and 42% vs 29%, respectively), compared with OSA patients with \'no nGER\'. The same pattern was seen in the general population, although with a generally lower prevalence. The effect of nGER on respiratory symptoms was similar between the two cohorts.
CONCLUSIONS: nGER was more often reported among untreated moderate-severe OSA patients than in the general population. Participants with nGER had more wheezing and productive cough, both among untreated OSA patients and in the general population.
METHODS: 2 study cohorts were included: 822 newly diagnosed subjects with moderate-severe OSA and 738 Icelandic general population study participants. All participants answered the same questionnaires. Those reporting nGER symptoms at least once per week were defined as \'with nGER\'; those without nGER symptoms and without nGER medication were defined as \'no nGER\'; and other participants were defined as having \'possible nGER\'. Propensity score-based weights were used to minimise confounding and selection bias and facilitate causal interpretations.
RESULTS: The prevalence of nGER among OSA patients was 14.1%, compared with 5.8% in the general population. This increased prevalence in OSA was not explained by differences in age, gender, body mass index, smoking, hypertension and diabetes (adjusted OR (95% CI)=3.79 (2.24 to 6.43)). OSA patients \'with nGER\' and with \'possible nGER\' reported more wheezing (44% and 44% vs 25%, respectively) and productive cough (47% and 42% vs 29%, respectively), compared with OSA patients with \'no nGER\'. The same pattern was seen in the general population, although with a generally lower prevalence. The effect of nGER on respiratory symptoms was similar between the two cohorts.
CONCLUSIONS: nGER was more often reported among untreated moderate-severe OSA patients than in the general population. Participants with nGER had more wheezing and productive cough, both among untreated OSA patients and in the general population.
摘要：
目的：评估未经治疗的阻塞性睡眠呼吸暂停（OSA）患者的呼吸道症状和夜间胃食管反流（nGER），与普通人群相比。此外，如果nGER与OSA患者的呼吸道症状有不同的相关性。
方法：2个研究队列包括：822名新诊断为中度-重度OSA的受试者和738名冰岛普通人群研究参与者。所有参与者都回答了相同的问卷。那些每周至少报告一次nGER症状的人被定义为“有nGER”；那些没有nGER症状且没有nGER药物的人被定义为“没有nGER”；其他参与者被定义为患有“可能的nGER”。使用基于倾向得分的权重来最大程度地减少混淆和选择偏差，并促进因果解释。
结果：OSA患者中nGER的患病率为14.1%，与普通人群的5.8%相比。OSA患病率的增加不能用年龄差异来解释，性别,身体质量指数,吸烟,高血压和糖尿病(校正OR(95%CI)=3.79(2.24~6.43))。患有“nGER”和“可能的nGER”的OSA患者报告了更多的喘息(44%和44%vs25%，分别)和生产性咳嗽(47%和42%vs29%，分别)，与“无nGER”的OSA患者相比。在普通人群中也看到了同样的模式，尽管患病率普遍较低。nGER对呼吸道症状的影响在两组之间相似。
结论：nGER在未经治疗的中重度OSA患者中比在一般人群中更常见。患有nGER的参与者有更多的喘息和生产性咳嗽，在未经治疗的OSA患者和普通人群中。
方法：2个研究队列包括：822名新诊断为中度-重度OSA的受试者和738名冰岛普通人群研究参与者。所有参与者都回答了相同的问卷。那些每周至少报告一次nGER症状的人被定义为“有nGER”；那些没有nGER症状且没有nGER药物的人被定义为“没有nGER”；其他参与者被定义为患有“可能的nGER”。使用基于倾向得分的权重来最大程度地减少混淆和选择偏差，并促进因果解释。
结果：OSA患者中nGER的患病率为14.1%，与普通人群的5.8%相比。OSA患病率的增加不能用年龄差异来解释，性别,身体质量指数,吸烟,高血压和糖尿病(校正OR(95%CI)=3.79(2.24~6.43))。患有“nGER”和“可能的nGER”的OSA患者报告了更多的喘息(44%和44%vs25%，分别)和生产性咳嗽(47%和42%vs29%，分别)，与“无nGER”的OSA患者相比。在普通人群中也看到了同样的模式，尽管患病率普遍较低。nGER对呼吸道症状的影响在两组之间相似。
结论：nGER在未经治疗的中重度OSA患者中比在一般人群中更常见。患有nGER的参与者有更多的喘息和生产性咳嗽，在未经治疗的OSA患者和普通人群中。
