Abstract：
Objective: To assess the impact of intravascular laser irradiation of blood (ILIB) on the primitive carotid artery (PCA) hemodynamic variables, specifically blood pressure (BP) and heart rate (HR), in mastectomized patients undergoing hormone blocker treatments. Materials and methods: This study is a controlled, experimental, and randomized clinical trial. Patients were allocated into two groups: the experimental group (G1)-patients who received ILIB therapy using a 660 nm laser targeted at the PCA, and the control group (G2)-patients who did not receive ILIB therapy. Clinical research was conducted weekly, with measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR. The Mann-Whitney U test for independent samples was used, with a significance level of α = 0.05. Results: Systemic photobiomodulation on the PCA did not demonstrate a statistically significant difference in relation to SBP and DBP. However, for HR, the p-value was <0.05, indicating a significant difference between G1 and G2. The initial mean p > decreased from 142.3 to 116.4 mmHg in G1, and from 130.4 to 119.8 mmHg in G2. The DBP varied from 78.8 to 72.8 mmHg in G1, and from 79.1 to 74.2 mmHg in G2. A statistically significant difference was observed in HR, decreasing from 81.3 to 62.06 bpm in G1, and changing minimally from 74.1 to 75.1 bpm in G2. A considerable reduction was present in the timing of application. Conclusions: ILIB therapy applied to the PCA induces a reduction in BP and, more notably, HR in mastectomized women using the tamoxifen or aromatase inhibitors.
摘要：
目的：评估血管内激光照射血液（ILIB）对原始颈动脉（PCA）血流动力学变量的影响。特别是血压（BP）和心率（HR），在接受激素阻滞剂治疗的乳房切除患者中。材料和方法：本研究是一项对照研究，实验性的,和随机临床试验。将患者分为两组：实验组（G1）-使用针对PCA的660nm激光接受ILIB治疗的患者，和对照组（G2）-未接受ILIB治疗的患者。临床研究每周进行一次，测量收缩压（SBP），舒张压（DBP），和HR。使用独立样本的Mann-WhitneyU检验，显著性水平为α=0.05。结果：PCA的全身光生物调节与SBP和DBP没有统计学上的显着差异。然而,HR,p值<0.05,表明G1和G2之间存在显著差异。初始平均值p>在G1中从142.3降至116.4mmHg，在G2中从130.4降至119.8mmHg。G1的DBP从78.8到72.8mmHg不等，G2的DBP从79.1到74.2mmHg不等。在HR方面观察到统计学上的显着差异，G1从81.3bpm降至62.06bpm，G2从74.1bpm降至75.1bpm。在应用时间上存在相当大的减少。结论：应用于PCA的ILIB治疗可降低BP，更值得注意的是,使用他莫昔芬或芳香化酶抑制剂的乳房切除妇女的HR。
