关键词: Autonomic neuronal modulation Cardiac arrhythmia Heart rate variability Nerve stimulation Neuromodulation

Mesh : Humans Atrial Fibrillation / therapy Heart Autonomic Nervous System / physiology Sympathetic Nervous System Heart Rate / physiology

来  源:   DOI:10.1016/j.physbeh.2024.114527

Abstract:
The pathophysiology of atrial fibrillation and ventricular tachycardia that result in cardiac arrhythmias is related to the sustained complicated mechanisms of the autonomic nervous system. Atrial fibrillation is when the heart beats irregularly, and ventricular arrhythmias are rapid and inconsistent heart rhythms, which involves many factors including the autonomic nervous system. It\'s a complex topic that requires careful exploration. Cultivation of speculative knowledge on atrial fibrillation; the irregular rhythm of the heart and ventricular arrhythmias; rapid oscillating waves resulting from mistakenly inconsistent P waves, and the inclusion of an autonomic nervous system is an inconceivable approach toward clinical intricacies. Autonomic modulation, therefore, acquires new expansions and conceptions of appealing therapeutic intelligence to prevent cardiac arrhythmia. Notably, autonomic modulation uses the neural tissue\'s flexibility to cause remodeling and, hence, provide therapeutic effects. In addition, autonomic modulation techniques included stimulation of the vagus nerve and tragus, renal denervation, cardiac sympathetic denervation, and baroreceptor activation treatment. Strong preclinical evidence and early human studies support the annihilation of cardiac arrhythmias by sympathetic and parasympathetic systems to transmigrate the cardiac myocytes and myocardium as efficient determinants at the cellular and physiological levels. However, the goal of this study is to draw attention to these promising early pre-clinical and clinical arrhythmia treatment options that use autonomic modulation as a therapeutic modality to conquer the troublesome process of irregular heart movements. Additionally, we provide a summary of the numerous techniques for measuring autonomic tone such as heart rate oscillations and its association with cutaneous sympathetic nerve activity appear to be substitute indicators and predictors of the outcome of treatment.
摘要:
导致心律失常的心房颤动和室性心动过速的病理生理学与自主神经系统的持续复杂机制有关。心房颤动是指心脏不规则跳动,室性心律失常是快速且不一致的心律,这涉及许多因素,包括自主神经系统。这是一个复杂的话题,需要仔细探索。对心房颤动的推测性知识的培养;心脏的不规则节律和室性心律失常;错误地不一致的P波导致的快速振荡波,包含自主神经系统是解决临床复杂性的一种不可思议的方法。自主调制,因此,获得新的扩展和吸引人的治疗智能概念,以防止心律失常。值得注意的是,自主调制利用神经组织的灵活性来引起重塑,因此,提供治疗效果。此外,自主调节技术包括刺激迷走神经和耳屏,去肾神经支配,心脏交感神经支配,和压力感受器激活治疗。强大的临床前证据和早期人类研究支持交感神经和副交感神经系统消灭心律失常,以迁移心肌细胞和心肌作为细胞和生理水平的有效决定因素。然而,本研究的目的是提请注意这些有前景的早期临床前和临床心律失常治疗方案,这些方案使用自主神经调节作为一种治疗方式,以克服心脏运动不规则的麻烦过程.此外,我们总结了许多测量自主神经张力的技术,如心率振荡及其与皮肤交感神经活动的关联,这些技术似乎是治疗结果的替代指标和预测因子。
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