Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions1.

在冷藏条件下冲击和振动对埃博拉疫苗最后一英里运输过程中产品质量的影响 1.

• 影响指数: 16.126
• 发表时间: 2024 Apr
• 来源期刊: Emerg Infect Dis
• DOI: 10.3201/eid3004.231060
• PMID: 38526137
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Bus-Jacobs L,Lau R,Soethoudt M,Gebbia L,Janssens E,Hermans T

关键词: Ebola vaccine; Ebola virus; Ebola virus disease; vaccine potency; vaccines; vibration; viruses

Mesh: Humans; Ebola Vaccines; Hemorrhagic Fever, Ebola / prevention & control; Ebolavirus; Vibration; Computer Simulation; Antibodies, Viral

Abstract

Analyzing vaccine stability under different storage and transportation conditions is critical to ensure that effectiveness and safety are not affected by distribution. In a simulation of the last mile in the supply chain, we found that shock and vibration had no effect on Ad26.ZEBOV/MVA-BN-Filo Ebola vaccine regimen quality under refrigerated conditions.

摘要

分析疫苗在不同储存和运输条件下的稳定性对于确保有效性和安全性不受分配影响至关重要。在供应链最后一英里的模拟中，我们发现冲击和振动对Ad26没有影响。ZEBOV/MVA-BN-Filo埃博拉疫苗方案在冷藏条件下的质量。