PDF(Pubmed)
Abstract：
Pyoderma gangrenosum is a rare inflammatory neutrophilic disorder with no uniformly effective therapy and limited high-level evidence. Common therapies include immunosuppressive and immunomodulating agents. There exist several case series using small molecules as treatment modalities. Here, we report a case of a 78-year-old female with a diagnosis of pyoderma gangrenosum and metastatic high-grade serous carcinoma of the ovary who was treated with Baricitinib 4 mg daily in combination with a tapering course of prednisone after failing other conventional therapies including systemic corticosteroids, colchicine, and intravenous immunoglobulin.
摘要：
坏疽性脓皮病是一种罕见的炎性嗜中性粒细胞疾病，没有统一有效的治疗方法和有限的高水平证据。常见的治疗包括免疫抑制剂和免疫调节剂。存在使用小分子作为治疗方式的几个病例系列。这里,我们报告了一例78岁女性，诊断为坏疽性脓皮病和转移性高级别卵巢浆液性癌，在其他常规治疗失败后，每天服用4mgBaricitinib联合逐渐减少泼尼松疗程，包括全身性皮质类固醇，秋水仙碱,和静脉注射免疫球蛋白.
