METHODS: In this registry study we focused on pregnant and postpartum patients with a history of prolonged duration of action of suxamethonium referred to the Danish Cholinesterase Research Unit (DCRU) between March 2007 and January 2023. Primary outcome was the proportion of patients without a mutation among patients with a low BChE activity. Secondary outcomes were the proportion of patients with a low BChE activity and the proportion of patients with a mutation out of the total number of patients.
RESULTS: A total of 40 patients were included and among patients with a low BChE activity, 6% (95% CI: 1%-21%) did not have a mutation. Out of the total number of included patients referred to the DCRU, 90% (95% CI: 76%-97%) had a mutation and 94% (95% CI: 80%-99%) had a low BChE activity.
CONCLUSIONS: Among pregnant and postpartum patients with a history of prolonged duration of action of suxamethonium and a low BChE activity, 6% did not have a mutation in the BChE gene. Our findings suggest that during pregnancy and postpartum clinically relevant prolonged duration of action of suxamethonium rarely occurs in genotypically normal patients.
方法:在这项注册研究中,我们关注的是在2007年3月至2023年1月期间,丹麦胆碱酯酶研究单位(DCRU)转诊的具有超敏酶作用持续时间延长的孕妇和产后患者。主要结果是BChE活性低的患者中无突变患者的比例。次要结果是BChE活性低的患者比例和突变患者占患者总数的比例。
结果:共纳入40例患者,其中BChE活性低的患者,6%(95%CI:1%-21%)没有突变。在转诊到DCRU的纳入患者总数中,90%(95%CI:76%-97%)具有突变,94%(95%CI:80%-99%)具有低BChE活性。
结论:在孕妇和产后患者中,有长期服用甲胺铵和低BChE活性的病史,6%的BChE基因没有突变。我们的发现表明,在基因型正常的患者中,在怀孕期间和产后临床相关的丁胺胺作用时间延长很少发生。