Abstract：
Cadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis in animals. In contrast, the reproductive toxicity of Cd in males and its mechanism of action have not been clarified. Therefore, this paper reviewed the toxic effects of Cd on germ cells, spermatogonia somatic cells and hypothalamic-pituitary-gonadal axis (HPG axis) of male animals and its toxic action mechanisms of oxidative stress, apoptosis and autophagy from the perspectives of cytology, genetics and neuroendocrinology. The effects of Cd stress on epigenetic modification of reproductive development in male animals were also analyzed. We hope to provide a reference for the in-depth study of the toxicity of Cd on male animal reproduction.
摘要：
镉(Cd)是环境中常见的重金属污染物,含Cd化合物的产品在工业中的广泛使用导致了环境中的含量超标，通过食物链进入动物体内，从而严重影响动物的生殖发育。相关研究报道Cd严重影响动物精原细胞发育和精子发生。相比之下,Cd对雄性的生殖毒性及其作用机制尚未阐明。因此,本文综述了Cd对生殖细胞的毒性作用,雄性动物的精原细胞和下丘脑-垂体-性腺轴（HPG轴）及其氧化应激的毒性作用机制，细胞凋亡和自噬从细胞学的角度来看，遗传学和神经内分泌学。还分析了Cd胁迫对雄性动物生殖发育表观遗传修饰的影响。希望为深入研究Cd对雄性动物繁殖的毒性提供参考。
