PDF(Pubmed)
Abstract：
BACKGROUND: Progestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF. More and more centres are using PPOS because this regimen appears simpler and cheaper. This study aims to compare the euploidy rate of blastocysts following the PPOS protocol and the gonadotropin-releasing hormone antagonist protocol in women undergoing preimplantation genetic testing for aneuploidy (PGT-A).
METHODS: This is a randomised trial. A total of 400 women undergoing PGT-A will be enrolled and randomised according to a computer-generated randomisation list to either (1) the antagonist group: an antagonist given once daily from day 6 of ovarian stimulation till the day of the ovulation trigger; or (2) the PPOS group: dydrogesterone from the first day of ovarian stimulation till the day of ovulation trigger. The primary outcome is the euploidy rate of blastocysts.
UNASSIGNED: An ethical approval was granted from the ethics committee of assisted reproductive medicine in Shanghai JiAi Genetics and IVF institute (JIAIE2020-03). A written informed consent will be obtained from each woman before any study procedure is performed, according to good clinical practice. The results of this randomised trial will be disseminated in a peer-reviewed journal.
BACKGROUND: NCT04414748.
METHODS: This is a randomised trial. A total of 400 women undergoing PGT-A will be enrolled and randomised according to a computer-generated randomisation list to either (1) the antagonist group: an antagonist given once daily from day 6 of ovarian stimulation till the day of the ovulation trigger; or (2) the PPOS group: dydrogesterone from the first day of ovarian stimulation till the day of ovulation trigger. The primary outcome is the euploidy rate of blastocysts.
UNASSIGNED: An ethical approval was granted from the ethics committee of assisted reproductive medicine in Shanghai JiAi Genetics and IVF institute (JIAIE2020-03). A written informed consent will be obtained from each woman before any study procedure is performed, according to good clinical practice. The results of this randomised trial will be disseminated in a peer-reviewed journal.
BACKGROUND: NCT04414748.
摘要：
背景：孕激素可以抑制体外受精（IVF）卵巢刺激过程中垂体黄体生成素（LH）的激增，研究表明孕激素引发的卵巢刺激（PPOS）可有效阻断IVF中LH的激增。越来越多的中心正在使用PPOS，因为这种方案看起来更简单，更便宜。这项研究旨在比较PPOS方案和促性腺激素释放激素拮抗剂方案在接受非整倍性植入前遗传测试（PGT-A）的女性中胚泡的整倍体率。
方法：这是一项随机试验。根据计算机生成的随机化列表，将总共招募400名接受PGT-A的妇女，并将其随机分配到（1）拮抗剂组：从卵巢刺激第6天到排卵触发日每天给予一次的拮抗剂；或（2）PPOS组：从卵巢刺激的第一天到排卵触发的那天，多屈孕酮。主要结果是胚泡的整倍体率。
■获得了上海嘉爱遗传与试管婴儿研究所辅助生殖医学伦理委员会的伦理批准（JIAIE2020-03）。在进行任何研究程序之前，将获得每位女性的书面知情同意书。根据良好的临床实践。这项随机试验的结果将在同行评审的期刊上发布。
背景：NCT04414748。
方法：这是一项随机试验。根据计算机生成的随机化列表，将总共招募400名接受PGT-A的妇女，并将其随机分配到（1）拮抗剂组：从卵巢刺激第6天到排卵触发日每天给予一次的拮抗剂；或（2）PPOS组：从卵巢刺激的第一天到排卵触发的那天，多屈孕酮。主要结果是胚泡的整倍体率。
■获得了上海嘉爱遗传与试管婴儿研究所辅助生殖医学伦理委员会的伦理批准（JIAIE2020-03）。在进行任何研究程序之前，将获得每位女性的书面知情同意书。根据良好的临床实践。这项随机试验的结果将在同行评审的期刊上发布。
背景：NCT04414748。
