Abstract：
Although the association between changes in human telomere length (TL) and ambient fine particulate matter (PM2.5) has been documented, there remains disagreement among the related literature. Our study conducted a systematic review and meta-analysis of epidemiological studies to investigate the health effects of outdoor PM2.5 exposure on human TL after a thorough database search. To quantify the overall effect estimates of TL changes associated with every 10 μg/m3 increase in PM2.5 exposure, we focused on two main topics, which were outdoor long-term exposure and prenatal exposure of PM2.5. Additionally, we included a summary of short-term PM2.5 exposure and its impact on TL due to limited data availability. Our qualitative analysis included 20 studies with 483,600 participants. The meta-analysis showed a statistically significant association between outdoor PM2.5 exposure and shorter human TL, with pooled impact estimates (β) of -0.12 (95% CI: -0.20, -0.03, I2= 95.4%) for general long-term exposure and -0.07 (95% CI: -0.15, 0.00, I2= 74.3%) for prenatal exposure. In conclusion, our findings suggest that outdoor PM2.5 exposure may contribute to TL shortening, and noteworthy associations were observed in specific subgroups, suggesting the impact of various research variables. Larger, high-quality studies using standardized methodologies are necessary to strengthen these conclusions further.
摘要：
尽管人类端粒长度（TL）的变化与环境细颗粒物（PM2.5）之间的关联已被证明，相关文献之间仍然存在分歧。我们的研究对流行病学研究进行了系统的回顾和荟萃分析，以在彻底的数据库搜索后调查室外PM2.5暴露对人类TL的健康影响。为了量化与PM2.5暴露量每增加10μg/m3相关的TL变化的总体效应估计，我们专注于两个主要主题，PM2.5的户外长期暴露和产前暴露。此外,由于数据有限,我们纳入了短期PM2.5暴露及其对TL的影响的总结.我们的定性分析包括20项研究，有483,600名参与者。荟萃分析显示，室外PM2.5暴露与较短的人类TL之间存在统计学上的显着关联，总体长期暴露的合并影响估计值（β）为-0.12（95％CI：-0.20，-0.03，I2=95.4％），产前暴露的-0.07（95％CI：-0.15，0.00，I2=74.3％）。总之,我们的研究结果表明，室外PM2.5暴露可能有助于TL缩短，在特定的亚组中观察到值得注意的关联，提示各种研究变量的影响。较大,使用标准化方法的高质量研究对于进一步加强这些结论是必要的。
