苯并咪唑取代的螺环丙基羟吲哚衍生物作为细胞毒性剂的发展 : 微管蛋白聚合抑制和凋亡诱导研究。
关键词: Anticancer Benzimidazole SAR (Structure activity relationship) Spirooxindoles Tubulin polymerase inhibition
Mesh : Humans Apoptosis / drug effects Antineoplastic Agents / pharmacology chemistry chemical synthesis Oxindoles / pharmacology chemistry chemical synthesis Tubulin / metabolism Tubulin Modulators / pharmacology chemistry chemical synthesis Drug Screening Assays, Antitumor Benzimidazoles / chemistry pharmacology chemical synthesis Structure-Activity Relationship Cell Proliferation / drug effects Polymerization / drug effects Molecular Structure Dose-Response Relationship, Drug Spiro Compounds / chemistry pharmacology chemical synthesis Cell Movement / drug effects Cell Line, Tumor Drug Development MCF-7 Cells
来 源: DOI:10.1002/cmdc.202400052