Abstract：
UNASSIGNED: Non-weight bearing improves and immobilization worsens contracture induced by anterior cruciate ligament reconstruction (ACLR), but effect persistence after reloading and remobilization remains unclear, and the combined effects of these factors on ACLR-induced contracture are unknown. We aimed to determine 1) whether the effects of short-term (2-week) non-weight bearing or immobilization after ACLR on contracture would be sustained by reloading or remobilization during a 10-week observation period, and 2) how the combination of both interventions compared to the outcome of either alone.
UNASSIGNED: We divided 88 ACL-reconstructed male rats into four groups: non-intervention, non-weight bearing, joint immobilization, and both interventions. Interventions were performed for 2 weeks, followed by rearing without intervention. Twelve untreated rats were used as controls. At 2, 4, and 12 weeks post-surgery, we assessed range of motion (ROM) and histological changes.
UNASSIGNED: ACLR resulted in persistent loss of ROM, accompanied by synovial shortening, capsule thickening, and osteophyte formation. Two weeks of non-weight bearing increased ROM and reduced osteophyte size, but the beneficial effects disappeared within 10 weeks after reloading. Two-week immobilization decreased ROM and facilitated synovial shortening. After remobilization, ROM partially recovered but remained below non-intervention levels at 12 weeks. When both interventions were combined, ROM was similar to immobilization alone.
UNASSIGNED: The beneficial effects of 2-week non-weight bearing on contracture diminished within 10 weeks after reloading. The adverse effects of 2-week immobilization on contracture persisted after 10 weeks of remobilization. The effects of the combined use of both interventions on contracture were primarily determined by immobilization.
UNASSIGNED: We divided 88 ACL-reconstructed male rats into four groups: non-intervention, non-weight bearing, joint immobilization, and both interventions. Interventions were performed for 2 weeks, followed by rearing without intervention. Twelve untreated rats were used as controls. At 2, 4, and 12 weeks post-surgery, we assessed range of motion (ROM) and histological changes.
UNASSIGNED: ACLR resulted in persistent loss of ROM, accompanied by synovial shortening, capsule thickening, and osteophyte formation. Two weeks of non-weight bearing increased ROM and reduced osteophyte size, but the beneficial effects disappeared within 10 weeks after reloading. Two-week immobilization decreased ROM and facilitated synovial shortening. After remobilization, ROM partially recovered but remained below non-intervention levels at 12 weeks. When both interventions were combined, ROM was similar to immobilization alone.
UNASSIGNED: The beneficial effects of 2-week non-weight bearing on contracture diminished within 10 weeks after reloading. The adverse effects of 2-week immobilization on contracture persisted after 10 weeks of remobilization. The effects of the combined use of both interventions on contracture were primarily determined by immobilization.
摘要：
■非负重改善了前交叉韧带重建（ACLR）引起的挛缩和固定恶化，但重新加载和重新动员后的持久性效果仍不清楚，这些因素对ACLR诱发挛缩的综合影响尚不清楚。我们的目的是确定1）在10周的观察期内，ACLR后短期（2周）非负重或固定对挛缩的影响是否可以通过重新加载或重新动员来维持，和2）两种干预措施的组合如何与单独两种干预措施的结果进行比较。
■我们将88只ACL重建的雄性大鼠分为四组：非干预，非承重，关节固定,两种干预措施。干预2周,其次是在没有干预的情况下饲养。12只未经处理的大鼠用作对照。在手术后2、4和12周，我们评估了活动范围（ROM）和组织学变化。
■ACLR导致ROM持续丢失，伴有滑膜缩短，胶囊增厚，和骨赘的形成。两周的非负重增加ROM和减少骨赘大小，但有益效果在重新加载后10周内消失。两周固定可减少ROM并促进滑膜缩短。重新动员后,ROM部分恢复，但在12周时仍低于非干预水平。当两种干预措施相结合时，ROM类似于单独固定。
■在重新加载后10周内，2周非负重对挛缩的有益作用减弱。重新固定10周后，2周固定对挛缩的不利影响持续存在。两种干预措施联合使用对挛缩的影响主要取决于固定。
■我们将88只ACL重建的雄性大鼠分为四组：非干预，非承重，关节固定,两种干预措施。干预2周,其次是在没有干预的情况下饲养。12只未经处理的大鼠用作对照。在手术后2、4和12周，我们评估了活动范围（ROM）和组织学变化。
■ACLR导致ROM持续丢失，伴有滑膜缩短，胶囊增厚，和骨赘的形成。两周的非负重增加ROM和减少骨赘大小，但有益效果在重新加载后10周内消失。两周固定可减少ROM并促进滑膜缩短。重新动员后,ROM部分恢复，但在12周时仍低于非干预水平。当两种干预措施相结合时，ROM类似于单独固定。
■在重新加载后10周内，2周非负重对挛缩的有益作用减弱。重新固定10周后，2周固定对挛缩的不利影响持续存在。两种干预措施联合使用对挛缩的影响主要取决于固定。
