UNASSIGNED: We divided 88 ACL-reconstructed male rats into four groups: non-intervention, non-weight bearing, joint immobilization, and both interventions. Interventions were performed for 2 weeks, followed by rearing without intervention. Twelve untreated rats were used as controls. At 2, 4, and 12 weeks post-surgery, we assessed range of motion (ROM) and histological changes.
UNASSIGNED: ACLR resulted in persistent loss of ROM, accompanied by synovial shortening, capsule thickening, and osteophyte formation. Two weeks of non-weight bearing increased ROM and reduced osteophyte size, but the beneficial effects disappeared within 10 weeks after reloading. Two-week immobilization decreased ROM and facilitated synovial shortening. After remobilization, ROM partially recovered but remained below non-intervention levels at 12 weeks. When both interventions were combined, ROM was similar to immobilization alone.
UNASSIGNED: The beneficial effects of 2-week non-weight bearing on contracture diminished within 10 weeks after reloading. The adverse effects of 2-week immobilization on contracture persisted after 10 weeks of remobilization. The effects of the combined use of both interventions on contracture were primarily determined by immobilization.
■我们将88只ACL重建的雄性大鼠分为四组:非干预,非承重,关节固定,两种干预措施。干预2周,其次是在没有干预的情况下饲养。12只未经处理的大鼠用作对照。在手术后2、4和12周,我们评估了活动范围(ROM)和组织学变化。
■ACLR导致ROM持续丢失,伴有滑膜缩短,胶囊增厚,和骨赘的形成。两周的非负重增加ROM和减少骨赘大小,但有益效果在重新加载后10周内消失。两周固定可减少ROM并促进滑膜缩短。重新动员后,ROM部分恢复,但在12周时仍低于非干预水平。当两种干预措施相结合时,ROM类似于单独固定。
■在重新加载后10周内,2周非负重对挛缩的有益作用减弱。重新固定10周后,2周固定对挛缩的不利影响持续存在。两种干预措施联合使用对挛缩的影响主要取决于固定。