Abstract：
<b>Background and Objective:</b> Lead poisoning (Pb) is a big problem because it is found in almost all objects in daily life such as vehicle fuel, water pipes, ceramics, cosmetics and others. Continuous lead exposure can increase ROS resulting in an increase in hepatic IL-6 and caspase 3 which replaces hepatic cell apoptosis. The objective of this study was to determine the effect of <i>Apium graveolens</i> (celery) extract on plasma IL-6 and hepatic caspase 3 levels. <b>Materials and Methods:</b> This study used a post-test control group design. The research subjects were 20 Wistar rats that met the inclusion criteria and were divided into 4 groups randomly, namely (a) Sham group that had no treatment, (b) Negative control group was induced with lead acetate 200 mg kg<sup>1</sup> body weight/day without any treatment (c) Positive control group and (d) Treated group. On the 15th day, blood was taken to check IL-6 levels and tissue was taken for liver caspase 3 examination by immunohistochemical method. Data analysis used the one-way ANOVA test and continued with the <i>post hoc</i> LSD test. <b>Results:</b> The highest mean caspase 3 expression was in the control group 45.84±4.39 pg mL<sup>1</sup>, while the mean of IL-6 plasma level was highest in the P1 641.33±39.72 pg mL<sup>1</sup> group. The Mann-Whitney test showed a significant difference in IL-6 levels between the study groups (p = 0.000). The Mann-Whitney test showed a significant difference in caspase 3 levels between the study groups (p = 0.000). <b>Conclusion:</b> Giving celery extract 300 mg kg<sup>1</sup> body weight/day affects plasma IL-6 and hepatic caspase 3 levels in lead acetate-induced rats.
摘要：
＆lt;b＆gt;背景和目标：＆lt;/b＆gt;铅中毒（Pb）是一个大问题，因为它几乎存在于日常生活中的所有物体中，例如车辆燃料，水管,陶瓷,化妆品和其他。持续的铅暴露可以增加ROS，导致肝脏IL-6和caspase3的增加，从而取代肝细胞凋亡。这项研究的目的是确定＆lt;i＆gt;罂粟＆lt;/i＆gt;（芹菜）提取物对血浆IL-6和肝半胱天冬酶3水平的影响。<b>材料与方法：</b>本研究采用试验后对照组设计。研究对象为20只符合纳入标准的Wistar大鼠,随机分为4组,即(A)没有治疗的假手术组，(b)阴性对照组用乙酸铅200mgkg<sup>1</sup>体重/天诱导,不进行任何处理(c)阳性对照组和(d)处理组。在第15天，取血检测IL-6水平,取组织进行肝脏caspase3免疫组化检测。数据分析使用单向方差分析检验，并继续使用<i>post</i>LSD检验。<b>结果:</b>对照组最高平均半胱天冬酶3表达量为45.84±4.39pgmL<sup>1</sup>,而IL-6血浆水平的平均值在P1641.33±39.72pgmL<sup>1</sup>组中最高。Mann-Whitney检验显示研究组之间IL-6水平的显著差异(p=0.000)。Mann-Whitney检验显示研究组之间的半胱天冬酶3水平存在显著差异(p=0.000)。<b>结论:</b>给予芹菜提取物300mgkg<sup>1</sup>体重/天影响醋酸铅诱导的大鼠血浆IL-6和肝半胱天冬酶3水平。
