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Abstract：
BACKGROUND: Pancreatic surgery is challenging owing to the anatomical characteristics of the pancreas. Increasing attention has been paid to changes in quality of life (QOL) after pancreatic surgery.
OBJECTIVE: To summarize and analyze current research results on QOL after pancreatic surgery.
METHODS: A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant studies were identified by screening the references of retrieved articles. Studies on patients\' QOL after pancreatic surgery published after January 1, 2012, were included. These included prospective and retrospective studies on patients\' QOL after several types of pancreatic surgeries. The results of these primary studies were summarized inductively.
RESULTS: A total of 45 articles were included in the study, of which 13 were related to pancreaticoduodenectomy (PD), seven to duodenum-preserving pancreatic head resection (DPPHR), nine to distal pancreatectomy (DP), two to central pancreatectomy (CP), and 14 to total pancreatectomy (TP). Some studies showed that 3-6 months were needed for QOL recovery after PD, whereas others showed that 6-12 months was more accurate. Although TP and PD had similar influences on QOL, patients needed longer to recover to preoperative or baseline levels after TP. The QOL was better after DPPHR than PD. However, the superiority of the QOL between patients who underwent CP and PD remains controversial. The decrease in exocrine and endocrine functions postoperatively was the main factor affecting the QOL. Minimally invasive surgery could improve patients\' QOL in the early stages after PD and DP; however, the long-term effect remains unclear.
CONCLUSIONS: The procedure among PD, DP, CP, and TP with a superior postoperative QOL is controversial. The long-term benefits of minimally invasive versus open surgeries remain unclear. Further prospective trials are warranted.
OBJECTIVE: To summarize and analyze current research results on QOL after pancreatic surgery.
METHODS: A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant studies were identified by screening the references of retrieved articles. Studies on patients\' QOL after pancreatic surgery published after January 1, 2012, were included. These included prospective and retrospective studies on patients\' QOL after several types of pancreatic surgeries. The results of these primary studies were summarized inductively.
RESULTS: A total of 45 articles were included in the study, of which 13 were related to pancreaticoduodenectomy (PD), seven to duodenum-preserving pancreatic head resection (DPPHR), nine to distal pancreatectomy (DP), two to central pancreatectomy (CP), and 14 to total pancreatectomy (TP). Some studies showed that 3-6 months were needed for QOL recovery after PD, whereas others showed that 6-12 months was more accurate. Although TP and PD had similar influences on QOL, patients needed longer to recover to preoperative or baseline levels after TP. The QOL was better after DPPHR than PD. However, the superiority of the QOL between patients who underwent CP and PD remains controversial. The decrease in exocrine and endocrine functions postoperatively was the main factor affecting the QOL. Minimally invasive surgery could improve patients\' QOL in the early stages after PD and DP; however, the long-term effect remains unclear.
CONCLUSIONS: The procedure among PD, DP, CP, and TP with a superior postoperative QOL is controversial. The long-term benefits of minimally invasive versus open surgeries remain unclear. Further prospective trials are warranted.
摘要：
背景：由于胰腺的解剖特征，胰腺手术具有挑战性。胰腺手术后生活质量（QOL）的变化越来越受到重视。
目的：总结分析胰腺手术后生活质量的研究现状。
方法：根据系统评价和荟萃分析指南的首选报告项目，对PubMed和EMBASE上的文献进行了系统检索。通过筛选检索到的文章的参考文献来确定相关研究。2012年1月1日后发表的胰腺手术后患者生活质量研究纳入研究。其中包括对几种类型胰腺手术后患者生活质量的前瞻性和回顾性研究。归纳总结了这些主要研究的结果。
结果：本研究共纳入45篇文章，其中13例与胰十二指肠切除术（PD）有关，7保留十二指肠的胰头切除术（DPPHR），九到远端胰腺切除术（DP），二到中央胰腺切除术（CP），14全胰腺切除术（TP）。一些研究表明，PD后QOL恢复需要3-6个月，而其他人则显示6-12个月更准确。尽管TP和PD对QOL有相似的影响，患者需要更长时间才能恢复到TP后的术前或基线水平.DPPHR后的生活质量优于PD。然而,接受CP和PD的患者的QOL优势仍存在争议.术后外分泌和内分泌功能下降是影响QOL的主要因素。微创手术可以改善PD和DP后早期患者的生活质量；然而，长期效果尚不清楚.
结论：PD之间的程序，DP,CP,TP具有优越的术后QOL是有争议的。微创手术与开放手术的长期益处尚不清楚。需要进一步的前瞻性试验。
目的：总结分析胰腺手术后生活质量的研究现状。
方法：根据系统评价和荟萃分析指南的首选报告项目，对PubMed和EMBASE上的文献进行了系统检索。通过筛选检索到的文章的参考文献来确定相关研究。2012年1月1日后发表的胰腺手术后患者生活质量研究纳入研究。其中包括对几种类型胰腺手术后患者生活质量的前瞻性和回顾性研究。归纳总结了这些主要研究的结果。
结果：本研究共纳入45篇文章，其中13例与胰十二指肠切除术（PD）有关，7保留十二指肠的胰头切除术（DPPHR），九到远端胰腺切除术（DP），二到中央胰腺切除术（CP），14全胰腺切除术（TP）。一些研究表明，PD后QOL恢复需要3-6个月，而其他人则显示6-12个月更准确。尽管TP和PD对QOL有相似的影响，患者需要更长时间才能恢复到TP后的术前或基线水平.DPPHR后的生活质量优于PD。然而,接受CP和PD的患者的QOL优势仍存在争议.术后外分泌和内分泌功能下降是影响QOL的主要因素。微创手术可以改善PD和DP后早期患者的生活质量；然而，长期效果尚不清楚.
结论：PD之间的程序，DP,CP,TP具有优越的术后QOL是有争议的。微创手术与开放手术的长期益处尚不清楚。需要进一步的前瞻性试验。
