PDF(Pubmed)
Abstract：
We conducted a prospective single-centre cohort study of 104 multi-ethnic severe COVID-19 survivors from the first wave of the pandemic 15 months after hospitalisation. Of those who were assessed at 4 and 15 months, improvement of ground glass opacities correlated with worsened fibrotic reticulations. Despite a high prevalence of fibrotic patterns (64%), pulmonary function, grip strength, 6 min walk distance and frailty normalised. Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies. Monitoring persistent, and often subclinical, fibrotic interstitial abnormalities will be needed to determine their potential for future progression.
摘要：
我们进行了一项前瞻性单中心队列研究，对住院15个月后第一波大流行的104名多种族重度COVID-19幸存者进行了研究。在4个月和15个月接受评估的人中，毛玻璃混浊的改善与纤维化网状结构恶化相关。尽管纤维化模式的患病率很高（64％），肺功能,握力,6分钟步行距离和脆弱正常化。总的来说,呼吸困难,咳嗽和疲惫没有改善，并且在15个月时与肺功能或影像学纤维化无关，提示非呼吸道病因。持续监控，通常是亚临床的，需要纤维化间质异常来确定其未来进展的潜力。
