Abstract：
The prevalence rate of allergic diseases including asthma, atopic rhinitis (AR) and atopic dermatitis (AD) has been significantly increasing in recent decades due to environmental changes and social developments. With the study of innate lymphoid cells, the crucial role played by type 2 innate lymphoid cells (ILC2s) have been progressively unveiled in allergic diseases. ILC2s, which are a subset of innate lymphocytes initiate allergic responses. They respond swiftly during the onset of allergic reactions and produce type 2 cytokines, working in conjunction with T helper type 2 (Th2) cells to induce and sustain type 2 immune responses. The role of ILC2s represents an intriguing frontier in immunology; however, the intricate immune mechanisms of ILC2s in allergic responses remain relatively poorly understood. To gain a comphrehensive understanding of the research progress of ILC2, we summarize recent advances in ILC2s biology in pathologic allergic inflammation to inspire novel approaches for managing allergic diseases.
摘要：
过敏性疾病包括哮喘的患病率,近几十年来,由于环境变化和社会发展,特应性鼻炎(AR)和特应性皮炎(AD)显著增加。随着对先天淋巴细胞的研究，2型先天淋巴样细胞（ILC2s）在过敏性疾病中的关键作用已逐渐显现。ILC2s,这是一个子集的先天淋巴细胞启动过敏反应。它们在过敏反应发作期间迅速反应并产生2型细胞因子，与T辅助型2（Th2）细胞一起工作，以诱导和维持2型免疫反应。ILC2s的作用代表了免疫学中一个有趣的前沿；然而，对ILC2s在过敏反应中的复杂免疫机制仍知之甚少.为了全面了解ILC2的研究进展，我们总结了ILC2s在病理性过敏性炎症中的生物学研究进展，以启发管理过敏性疾病的新方法。
