Abstract：
Cerebral ischemia produces a decrease, loss, or instability of the assembly processes in the neuronal cytoskeleton, related to the alteration in the normal processes of phosphorylation of the Tau protein, triggering its hyperphosphorylation and altering the normal processes of formation of neuronal microtubules. Here we describe the methods used to study the impact of middle cerebral artery occlusion (MCAo) on neurological functions and Tau phosphorylation in Wistar rat brain.
摘要：
脑缺血产生减少，损失,或神经元细胞骨架组装过程的不稳定性，与Tau蛋白正常磷酸化过程的改变有关，触发其过度磷酸化并改变神经元微管形成的正常过程。在这里，我们描述了用于研究大脑中动脉闭塞（MCAo）对Wistar大鼠大脑中神经功能和Tau磷酸化的影响的方法。
