Abstract：
Parkinson\'s disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of brain regions and neuronal circuits. Meanwhile, there are updates in deep brain stimulation (DBS) and other factors for the motor improvement in PD. Comprehensive understandings of brain regions and neuronal circuits involved in motor control could benefit the development of novel therapeutical strategies in PD.
摘要：
帕金森病（PD）是一种进行性神经退行性疾病，具有全球性负担，在老年人中更常受到影响。基底神经节（BG）被认为是PD中运动障碍的原因。最近,在BG涉及运动控制的原始区域的新发现，以及以前没有特别考虑的新电路或新核子被探索。在本次审查中，我们提供与运动障碍和PD调制相关的最新信息，特别是从大脑区域和神经元回路的角度来看。同时,深部脑刺激（DBS）和其他改善PD运动的因素有了更新。对运动控制中涉及的大脑区域和神经元回路的全面了解可能有利于PD新型治疗策略的开发。
