PDF(Pubmed)
Abstract：
UNASSIGNED: Current treatment for knee Osteoarthritis (OA) includes exercise and intra-articular injections with corticosteroid (CS), hyaluronic acid (HA), etc., which address OA-related pain and functional limitation. While these interventions can be given together, little is known about the efficacy of a multi-modal approach. The purpose of this scoping review is to examine studies that compare combining exercise and intra-articular knee injections to exercise alone for the management of knee OA.
UNASSIGNED: A search was performed using PubMed, CINAHL, and Clinicaltrials.gov with MeSH terms \"knee osteoarthritis\" AND \"exercise\" AND \"injections\". Abstracts were screened to meet inclusion criteria of both intervention groups including exercise and one group receiving an injection for treatment of knee OA. Full text articles were screened to meet inclusion criteria and rated using the Pedro Scale.
UNASSIGNED: 11 studies that met inclusion criteria. The included studies utilized CS, hyaluronic acid (HA), and Bone Marrow Concentrate (BMC), botulinum toxin A, or a combination of dextrose and lidocaine injections. Most studies included supervised exercise interventions with all studies including strengthening of the quadriceps. CS and exercise compared to exercise alone showed similar improvements in pain. The HA injection studies yielded mixed results with two studies finding HA and exercise was not superior than exercise alone while two other studies found that HA and exercise were superior.
UNASSIGNED: There was a paucity of literature investigating multimodal approaches. Most of the included studies did not find superior effects of adding a knee injection to exercise compared to exercise alone for knee OA.
UNASSIGNED: A search was performed using PubMed, CINAHL, and Clinicaltrials.gov with MeSH terms \"knee osteoarthritis\" AND \"exercise\" AND \"injections\". Abstracts were screened to meet inclusion criteria of both intervention groups including exercise and one group receiving an injection for treatment of knee OA. Full text articles were screened to meet inclusion criteria and rated using the Pedro Scale.
UNASSIGNED: 11 studies that met inclusion criteria. The included studies utilized CS, hyaluronic acid (HA), and Bone Marrow Concentrate (BMC), botulinum toxin A, or a combination of dextrose and lidocaine injections. Most studies included supervised exercise interventions with all studies including strengthening of the quadriceps. CS and exercise compared to exercise alone showed similar improvements in pain. The HA injection studies yielded mixed results with two studies finding HA and exercise was not superior than exercise alone while two other studies found that HA and exercise were superior.
UNASSIGNED: There was a paucity of literature investigating multimodal approaches. Most of the included studies did not find superior effects of adding a knee injection to exercise compared to exercise alone for knee OA.
摘要：
■目前治疗膝骨关节炎（OA）包括运动和关节内注射皮质类固醇（CS），透明质酸（HA），等。,解决OA相关的疼痛和功能限制。虽然这些干预措施可以放在一起，对多模式方法的有效性知之甚少。这项范围审查的目的是研究比较运动和关节内注射与单独运动治疗膝关节OA的研究。
■使用PubMed进行了搜索，CINAHL,和Clinicaltrials.gov带有MeSH术语“膝盖骨关节炎”和“运动”和“注射”。筛选摘要，以满足两个干预组的纳入标准，包括运动和一组接受注射治疗膝关节OA。筛选符合纳入标准的全文文章，并使用Pedro量表进行评级。
■11项符合纳入标准的研究。纳入的研究利用CS，透明质酸（HA），和骨髓浓缩物（BMC），肉毒杆菌毒素A,或葡萄糖和利多卡因注射的组合。大多数研究包括监督运动干预，所有研究包括加强股四头肌。与单纯运动相比，CS和运动在疼痛方面表现出相似的改善。HA注射研究产生了混合的结果，其中两项研究发现HA和运动并不比单独运动优越，而另外两项研究发现HA和运动优越。
■研究多模态方法的文献很少。大多数纳入的研究没有发现与单独运动相比，在膝关节OA中增加膝关节注射的效果更好。
■使用PubMed进行了搜索，CINAHL,和Clinicaltrials.gov带有MeSH术语“膝盖骨关节炎”和“运动”和“注射”。筛选摘要，以满足两个干预组的纳入标准，包括运动和一组接受注射治疗膝关节OA。筛选符合纳入标准的全文文章，并使用Pedro量表进行评级。
■11项符合纳入标准的研究。纳入的研究利用CS，透明质酸（HA），和骨髓浓缩物（BMC），肉毒杆菌毒素A,或葡萄糖和利多卡因注射的组合。大多数研究包括监督运动干预，所有研究包括加强股四头肌。与单纯运动相比，CS和运动在疼痛方面表现出相似的改善。HA注射研究产生了混合的结果，其中两项研究发现HA和运动并不比单独运动优越，而另外两项研究发现HA和运动优越。
■研究多模态方法的文献很少。大多数纳入的研究没有发现与单独运动相比，在膝关节OA中增加膝关节注射的效果更好。
