METHODS: Electronic medical records of hospitalized patients in three prominent medical centers in India (Fortis Memorial Research Centre, Gurugram, S L Raheja Hospital, Mumbai, and Fortis Hospital, Anandapur, Kolkata) with nosocomial pneumonia and documented gram-negative Klebsiella pneumoniae (KP)-confirmed infection were collected. This study assessed the effectiveness, usage pattern of ceftazidime-avibactam, and clinical and microbiological cure rates.
RESULTS: Among the 116 patients included, 78.45% (91/116) showed clinical cure. Microbiological cure was observed in nine out of 13 (69.23%) patients. In the subset analysis, a clinical cure rate of 84.85% (28/33) and microbiological recovery rate of 62.50% (5/8) were observed when ceftazidime-avibactam was initiated within 72 hours of diagnosis. Ceftazidime-avibactam was administered for a mean (±SD) duration of 7.79 ± 4.43 days, with improvement in signs and symptoms reported among 91.38% (106/116). Ceftazidime-avibactam showed a susceptibility of 56% (28/56) in the study.
CONCLUSIONS: The current study showed a better clinical and microbiological cure rate with a safer tolerability profile of ceftazidime-avibactam in carbapenem-resistant KP nosocomial pneumonia and VAP. This study has further demonstrated that ceftazidime-avibactam may be used as one of the viable treatment choices in carbapenem-resistant KP with favorable clinical outcomes.
方法:印度三个著名医疗中心住院患者的电子病历(富通纪念研究中心,Gurugram,SLRaheja医院,孟买,和富通医院,Anandapur,收集了加尔各答)医院获得性肺炎和记录的革兰氏阴性肺炎克雷伯菌(KP)证实的感染。这项研究评估了有效性,头孢他啶-阿维巴坦的使用模式,以及临床和微生物治愈率。
结果:在116名患者中,78.45%(91/116)显示临床治愈。13例患者中有9例(69.23%)观察到微生物治愈。在子集分析中,在诊断后72小时内开始使用头孢他啶-阿维巴坦,临床治愈率为84.85%(28/33),微生物回收率为62.50%(5/8)。头孢他啶-阿维巴坦的平均(±SD)时间为7.79±4.43天,在91.38%(106/116)中报告了体征和症状的改善。头孢他啶-阿维巴坦在研究中显示56%(28/56)的易感性。
结论:本研究显示头孢他啶-阿维巴坦在耐碳青霉烯的KP医院性肺炎和VAP中的临床和微生物治愈率较高,耐受性较安全。这项研究进一步证明,头孢他啶-阿维巴坦可作为碳青霉烯类耐药KP的可行治疗选择之一,具有良好的临床疗效。