PDF(Pubmed)
Abstract：
UNASSIGNED: The reconstruction of frontobasal defects following oncologic resections of paranasal and anterior skull base (ASB) malignancies remains challenging. Ineffective reconstruction could lead to cerebrospinal fluid leak, meningitis, and tension pneumocephalus.
UNASSIGNED: Aim of this investigation was to analyse postoperative complication rates with or without bone graft for anterior skull base reconstruction.
UNASSIGNED: In this retrospective study, we included patients following resection of paranasal and/or anterior skull base malignancies between October 2013 and December 2022. Complications were analysed with regards to the type of skull base reconstruction.
UNASSIGNED: Eleven patients were identified (2 female, 9 male, age (median, SD) 64 ± 14.1 years (range 38-81). There were nine cases of paranasal sinus and nasal cavity carcinomas and two cases of olfactory neuroblastomas. Overall survival was 22.5 ± 28 months (range: 5-78), progression free survival was 17.0 ± 20.3 months (range: 11-78). Bone skull base reconstruction using a split graft was performed in three cases. Postoperative complications requiring surgical intervention were seen in 33% (one tension pneumocephalus) of cases in the bone reconstruction group and 50% (three patients with cerebrospinal fluid leak, one infection) in the non-bone reconstruction group.
UNASSIGNED: The structural reinforcement of structural bone chip grafting might provide additional support of the ASB and prevent CSF leakage or encephalocele. Especially in large (>10 cm2) bone defects of advanced sinonasal malignancies extending into the middle cranial fossa, the full armamentarium of reconstruction possibilities should be considered.
UNASSIGNED: Aim of this investigation was to analyse postoperative complication rates with or without bone graft for anterior skull base reconstruction.
UNASSIGNED: In this retrospective study, we included patients following resection of paranasal and/or anterior skull base malignancies between October 2013 and December 2022. Complications were analysed with regards to the type of skull base reconstruction.
UNASSIGNED: Eleven patients were identified (2 female, 9 male, age (median, SD) 64 ± 14.1 years (range 38-81). There were nine cases of paranasal sinus and nasal cavity carcinomas and two cases of olfactory neuroblastomas. Overall survival was 22.5 ± 28 months (range: 5-78), progression free survival was 17.0 ± 20.3 months (range: 11-78). Bone skull base reconstruction using a split graft was performed in three cases. Postoperative complications requiring surgical intervention were seen in 33% (one tension pneumocephalus) of cases in the bone reconstruction group and 50% (three patients with cerebrospinal fluid leak, one infection) in the non-bone reconstruction group.
UNASSIGNED: The structural reinforcement of structural bone chip grafting might provide additional support of the ASB and prevent CSF leakage or encephalocele. Especially in large (>10 cm2) bone defects of advanced sinonasal malignancies extending into the middle cranial fossa, the full armamentarium of reconstruction possibilities should be considered.
摘要：
■鼻旁和前颅底（ASB）恶性肿瘤的肿瘤切除后重建额基底缺损仍然具有挑战性。重建无效会导致脑脊液漏,脑膜炎,和张力性气颅。
■这项研究的目的是分析有或没有植骨的前颅底重建术后并发症的发生率。
■在这项回顾性研究中，我们纳入了2013年10月至2022年12月期间鼻旁和/或前颅底恶性肿瘤切除术后的患者.分析了有关颅底重建类型的并发症。
■确定了11名患者（2名女性，9男,年龄(中位数，SD)64±14.1年(范围38-81)。鼻旁窦和鼻腔癌9例，嗅神经母细胞瘤2例。总生存期为22.5±28个月（范围：5-78），无进展生存期为17.0±20.3个月(范围:11-78).在三例病例中，使用分裂移植物进行了骨颅底重建。需要手术干预的术后并发症在骨重建组中占33％（1张力性气颅）和50％（3例脑脊液漏，一种感染）在非骨重建组中。
■结构骨碎片移植的结构增强可能为ASB提供额外的支持，并防止CSF渗漏或脑膨出。尤其是在扩展到中颅窝的晚期鼻窦恶性肿瘤的大（>10cm2）骨缺损中，应该考虑重建可能性的完整武器库。
■这项研究的目的是分析有或没有植骨的前颅底重建术后并发症的发生率。
■在这项回顾性研究中，我们纳入了2013年10月至2022年12月期间鼻旁和/或前颅底恶性肿瘤切除术后的患者.分析了有关颅底重建类型的并发症。
■确定了11名患者（2名女性，9男,年龄(中位数，SD)64±14.1年(范围38-81)。鼻旁窦和鼻腔癌9例，嗅神经母细胞瘤2例。总生存期为22.5±28个月（范围：5-78），无进展生存期为17.0±20.3个月(范围:11-78).在三例病例中，使用分裂移植物进行了骨颅底重建。需要手术干预的术后并发症在骨重建组中占33％（1张力性气颅）和50％（3例脑脊液漏，一种感染）在非骨重建组中。
■结构骨碎片移植的结构增强可能为ASB提供额外的支持，并防止CSF渗漏或脑膨出。尤其是在扩展到中颅窝的晚期鼻窦恶性肿瘤的大（>10cm2）骨缺损中，应该考虑重建可能性的完整武器库。
