%0 Journal Article
%T Dural reconstruction with or without a bone graft of paranasal and anterior skullbase malignancies: Retrospective single-center analysis of 11 cases and review of literature.
%A Sommer B
%A Konietzko I
%A Bonk MN
%A Schaller T
%A Märkl B
%A Kahl KH
%A Stüben G
%A Zenk J
%A Shiban E
%J Brain Spine
%V 4
%N 0
%D 2024
%M 38510629
暂无%R 10.1016/j.bas.2023.102740
%X <B>UNASSIGNED: </B>The reconstruction of frontobasal defects following oncologic resections of paranasal and anterior skull base (ASB) malignancies remains challenging. Ineffective reconstruction could lead to cerebrospinal fluid leak, meningitis, and tension pneumocephalus.<BR><B>UNASSIGNED: </B>Aim of this investigation was to analyse postoperative complication rates with or without bone graft for anterior skull base reconstruction.<BR><B>UNASSIGNED: </B>In this retrospective study, we included patients following resection of paranasal and/or anterior skull base malignancies between October 2013 and December 2022. Complications were analysed with regards to the type of skull base reconstruction.<BR><B>UNASSIGNED: </B>Eleven patients were identified (2 female, 9 male, age (median, SD) 64 ± 14.1 years (range 38-81). There were nine cases of paranasal sinus and nasal cavity carcinomas and two cases of olfactory neuroblastomas. Overall survival was 22.5 ± 28 months (range: 5-78), progression free survival was 17.0 ± 20.3 months (range: 11-78). Bone skull base reconstruction using a split graft was performed in three cases. Postoperative complications requiring surgical intervention were seen in 33% (one tension pneumocephalus) of cases in the bone reconstruction group and 50% (three patients with cerebrospinal fluid leak, one infection) in the non-bone reconstruction group.<BR><B>UNASSIGNED: </B>The structural reinforcement of structural bone chip grafting might provide additional support of the ASB and prevent CSF leakage or encephalocele. Especially in large (>10 cm2) bone defects of advanced sinonasal malignancies extending into the middle cranial fossa, the full armamentarium of reconstruction possibilities should be considered.