PDF(Pubmed)
Abstract：
UNASSIGNED: Patients with hypertrophic cardiomyopathy (HCM) are generally regarded as having increased risk of arrhythmia, stroke, heart failure, and sudden cardiac death, but reported mortality rates vary considerably and originate from selected populations.
UNASSIGNED: We aimed to investigate the long-term mortality rate in a nationwide cohort of patients with HCM compared to a matched cohort from the general Danish population.
UNASSIGNED: All patients with a first-time HCM diagnosis in Denmark between January 1, 2007 and December 31, 2018 were identified through nationwide registries. In the main analysis, two visits in an outpatient clinic were required in order to increase specificity. Patients were matched to controls from the background population in a 1:3 ratio based on age, sex, selected comorbidities and date of HCM. Mortalities were compared using Kaplan Meier estimator and multivariable Cox regression models.
UNASSIGNED: We identified 3126 patients with a first-time diagnosis of HCM. 1197 patients had at least two visits in the outpatient clinic (43 % female, median age 63.1 [25th-75th percentile 52.1-72.1] years). All-cause mortality was significantly higher in HCM patients than in matched controls: 10-year probabilities of death were 36.4 % (95 % CI 30.2-43.5 %) for HCM patients and 19.4 % (95 % CI 16.8-22.5 %) for controls. After adjusting for additional comorbidities and medications, a diagnosis with HCM was associated with an increased mortality rate (HR 1.48 (95 % CI 1.18-1.84, p = 0.001)).
UNASSIGNED: Compared to matched controls from the background population, presence of HCM was associated with a significant increase in mortality rate.
UNASSIGNED: We aimed to investigate the long-term mortality rate in a nationwide cohort of patients with HCM compared to a matched cohort from the general Danish population.
UNASSIGNED: All patients with a first-time HCM diagnosis in Denmark between January 1, 2007 and December 31, 2018 were identified through nationwide registries. In the main analysis, two visits in an outpatient clinic were required in order to increase specificity. Patients were matched to controls from the background population in a 1:3 ratio based on age, sex, selected comorbidities and date of HCM. Mortalities were compared using Kaplan Meier estimator and multivariable Cox regression models.
UNASSIGNED: We identified 3126 patients with a first-time diagnosis of HCM. 1197 patients had at least two visits in the outpatient clinic (43 % female, median age 63.1 [25th-75th percentile 52.1-72.1] years). All-cause mortality was significantly higher in HCM patients than in matched controls: 10-year probabilities of death were 36.4 % (95 % CI 30.2-43.5 %) for HCM patients and 19.4 % (95 % CI 16.8-22.5 %) for controls. After adjusting for additional comorbidities and medications, a diagnosis with HCM was associated with an increased mortality rate (HR 1.48 (95 % CI 1.18-1.84, p = 0.001)).
UNASSIGNED: Compared to matched controls from the background population, presence of HCM was associated with a significant increase in mortality rate.
摘要：
■患有肥厚型心肌病（HCM）的患者通常被认为具有增加的心律失常风险，中风,心力衰竭,和心源性猝死,但是报告的死亡率差异很大，并且来自选定的人群。
■我们旨在调查全国HCM患者队列与丹麦普通人群的匹配队列的长期死亡率。
2007年1月1日至2018年12月31日在丹麦首次诊断为HCM的所有患者均通过全国注册登记。在主要分析中，为了提高特异性,我们需要在门诊就诊两次.根据年龄，患者以1：3的比例与背景人群的对照组相匹配，性别,选定的合并症和HCM的日期。使用KaplanMeier估计和多变量Cox回归模型比较死亡率。
■我们确定了3126例首次诊断为HCM的患者。1197名患者至少有两次在门诊就诊（43%为女性，中位年龄63.1[第25-75百分位数52.1-72.1]岁）。HCM患者的全因死亡率明显高于对照组：HCM患者的10年死亡概率为36.4％（95％CI30.2-43.5％），对照组为19.4％（95％CI16.8-22.5％）。在调整额外的合并症和药物后，HCM诊断与死亡率增加相关(HR1.48(95%CI1.18~1.84,p=0.001)).
■与来自背景人群的匹配对照相比，HCM的存在与死亡率的显著增加相关.
■我们旨在调查全国HCM患者队列与丹麦普通人群的匹配队列的长期死亡率。
2007年1月1日至2018年12月31日在丹麦首次诊断为HCM的所有患者均通过全国注册登记。在主要分析中，为了提高特异性,我们需要在门诊就诊两次.根据年龄，患者以1：3的比例与背景人群的对照组相匹配，性别,选定的合并症和HCM的日期。使用KaplanMeier估计和多变量Cox回归模型比较死亡率。
■我们确定了3126例首次诊断为HCM的患者。1197名患者至少有两次在门诊就诊（43%为女性，中位年龄63.1[第25-75百分位数52.1-72.1]岁）。HCM患者的全因死亡率明显高于对照组：HCM患者的10年死亡概率为36.4％（95％CI30.2-43.5％），对照组为19.4％（95％CI16.8-22.5％）。在调整额外的合并症和药物后，HCM诊断与死亡率增加相关(HR1.48(95%CI1.18~1.84,p=0.001)).
■与来自背景人群的匹配对照相比，HCM的存在与死亡率的显著增加相关.
