PDF(Pubmed)
Abstract：
UNASSIGNED: This study investigated whether schizophrenia and the duration of schizophrenia were associated with cardiovascular autonomic neuropathy (CAN) by using heart rate variability (HRV) as a marker.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: The examinations were conducted at the Centre for Psychosis Research and at the Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
UNASSIGNED: 240 patients with first-episode and chronic schizophrenia and 180 controls.
UNASSIGNED: CAN was assessed by the cardiovascular reflex tests (CARTs): HR, RS ratio, E:I ratio, and VM using a handheld device.
UNASSIGNED: One abnormal CART was interpreted as borderline CAN and ≥2 abnormal CARTs established definitive CAN. Borderline CAN and definitive CAN together was categorized as overall CAN. Analyses were adjusted for age, sex, smoking, overweight, and hypercholesterolemia.
UNASSIGNED: A total of 240 patients with schizophrenia (median age 42.5 [28.8, 52.3], 42.9 % women) and 180 controls (median age 45.8 [24.0, 60.1], 47.8 % women) were included, with 50.8 % of patients with schizophrenia having overall CAN compared to 27.2 % among controls. Dividing patients into patients with first-episode and chronic schizophrenia, 32.9 % vs 10 % (p < 0.001) and 59.1 % vs 41 % (p < 0.001) had overall CAN compared with controls, respectively. Schizophrenia was significantly associated with overall CAN (OR, 2.80; 95%CI, 1.75-4.50), with an OR of 2.31 (95%CI, 1.14-4.68) for first-episode schizophrenia and an OR of 2.97 (95%CI, 1.81-4.87) for chronic schizophrenia.
UNASSIGNED: It was demonstrated that a diagnosis of schizophrenia was associated with CAN. Patients with chronic schizophrenia had a significantly higher prevalence of CAN compared to patients with first-episode schizophrenia, suggesting an association between the duration of schizophrenia and CAN.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: The examinations were conducted at the Centre for Psychosis Research and at the Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
UNASSIGNED: 240 patients with first-episode and chronic schizophrenia and 180 controls.
UNASSIGNED: CAN was assessed by the cardiovascular reflex tests (CARTs): HR, RS ratio, E:I ratio, and VM using a handheld device.
UNASSIGNED: One abnormal CART was interpreted as borderline CAN and ≥2 abnormal CARTs established definitive CAN. Borderline CAN and definitive CAN together was categorized as overall CAN. Analyses were adjusted for age, sex, smoking, overweight, and hypercholesterolemia.
UNASSIGNED: A total of 240 patients with schizophrenia (median age 42.5 [28.8, 52.3], 42.9 % women) and 180 controls (median age 45.8 [24.0, 60.1], 47.8 % women) were included, with 50.8 % of patients with schizophrenia having overall CAN compared to 27.2 % among controls. Dividing patients into patients with first-episode and chronic schizophrenia, 32.9 % vs 10 % (p < 0.001) and 59.1 % vs 41 % (p < 0.001) had overall CAN compared with controls, respectively. Schizophrenia was significantly associated with overall CAN (OR, 2.80; 95%CI, 1.75-4.50), with an OR of 2.31 (95%CI, 1.14-4.68) for first-episode schizophrenia and an OR of 2.97 (95%CI, 1.81-4.87) for chronic schizophrenia.
UNASSIGNED: It was demonstrated that a diagnosis of schizophrenia was associated with CAN. Patients with chronic schizophrenia had a significantly higher prevalence of CAN compared to patients with first-episode schizophrenia, suggesting an association between the duration of schizophrenia and CAN.
摘要：
■这项研究通过使用心率变异性（HRV）作为标志物来调查精神分裂症和精神分裂症的持续时间是否与心血管自主神经病变（CAN）相关。
■横断面研究。
■检查是在精神病研究中心和心脏病学部门进行的，奥尔堡大学医院,奥尔堡,丹麦。
■240例首发和慢性精神分裂症患者和180例对照。
■通过心血管反射测试（CART）评估CAN：HR，RS比率,E:I比,和VM使用手持设备。
■一个异常CART被解释为临界CAN，≥2个异常CART确定了CAN。边界线CAN和最终CAN一起被归类为整体CAN。分析根据年龄进行了调整，性别,吸烟,超重,和高胆固醇血症.
■共有240名精神分裂症患者（中位年龄42.5[28.8,52.3]，42.9%的女性）和180名对照（中位年龄45.8[24.0，60.1]，47.8％的妇女）被包括在内，50.8%的精神分裂症患者有总体CAN，而对照组为27.2%。将患者分为首发和慢性精神分裂症患者，与对照组相比，32.9％vs10％（p<0.001）和59.1％vs41％（p<0.001）的总体CAN，分别。精神分裂症与整体CAN（OR，2.80；95CI，1.75-4.50），首发精神分裂症的OR为2.31（95CI，1.14-4.68），慢性精神分裂症的OR为2.97（95CI，1.81-4.87）。
■已证明精神分裂症的诊断与CAN有关。慢性精神分裂症患者的CAN患病率明显高于首发精神分裂症患者,表明精神分裂症的持续时间与CAN之间存在关联。
■横断面研究。
■检查是在精神病研究中心和心脏病学部门进行的，奥尔堡大学医院,奥尔堡,丹麦。
■240例首发和慢性精神分裂症患者和180例对照。
■通过心血管反射测试（CART）评估CAN：HR，RS比率,E:I比,和VM使用手持设备。
■一个异常CART被解释为临界CAN，≥2个异常CART确定了CAN。边界线CAN和最终CAN一起被归类为整体CAN。分析根据年龄进行了调整，性别,吸烟,超重,和高胆固醇血症.
■共有240名精神分裂症患者（中位年龄42.5[28.8,52.3]，42.9%的女性）和180名对照（中位年龄45.8[24.0，60.1]，47.8％的妇女）被包括在内，50.8%的精神分裂症患者有总体CAN，而对照组为27.2%。将患者分为首发和慢性精神分裂症患者，与对照组相比，32.9％vs10％（p<0.001）和59.1％vs41％（p<0.001）的总体CAN，分别。精神分裂症与整体CAN（OR，2.80；95CI，1.75-4.50），首发精神分裂症的OR为2.31（95CI，1.14-4.68），慢性精神分裂症的OR为2.97（95CI，1.81-4.87）。
■已证明精神分裂症的诊断与CAN有关。慢性精神分裂症患者的CAN患病率明显高于首发精神分裂症患者,表明精神分裂症的持续时间与CAN之间存在关联。
