{Reference Type}: Journal Article
{Title}: Cardiovascular autonomic reflex tests using a handheld device in the diagnosis of cardiovascular autonomic neuropathy in patients with schizophrenia.
{Author}: Blok-Husum L;Brcelic MAR;Bassi HKFK;Jensen SE;Nielsen RE;Kragholm K;Fleischer J;Laugesen E;Polcwiartek C;
{Journal}: Am Heart J Plus
{Volume}: 26
{Issue}: 0
{Year}: 2023 Feb
暂无{DOI}: 10.1016/j.ahjo.2023.100252
{Abstract}: <B>UNASSIGNED: </B>This study investigated whether schizophrenia and the duration of schizophrenia were associated with cardiovascular autonomic neuropathy (CAN) by using heart rate variability (HRV) as a marker.<BR><B>UNASSIGNED: </B>Cross-sectional study.<BR><B>UNASSIGNED: </B>The examinations were conducted at the Centre for Psychosis Research and at the Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.<BR><B>UNASSIGNED: </B>240 patients with first-episode and chronic schizophrenia and 180 controls.<BR><B>UNASSIGNED: </B>CAN was assessed by the cardiovascular reflex tests (CARTs): HR, RS ratio, E:I ratio, and VM using a handheld device.<BR><B>UNASSIGNED: </B>One abnormal CART was interpreted as borderline CAN and ≥2 abnormal CARTs established definitive CAN. Borderline CAN and definitive CAN together was categorized as overall CAN. Analyses were adjusted for age, sex, smoking, overweight, and hypercholesterolemia.<BR><B>UNASSIGNED: </B>A total of 240 patients with schizophrenia (median age 42.5 [28.8, 52.3], 42.9 % women) and 180 controls (median age 45.8 [24.0, 60.1], 47.8 % women) were included, with 50.8 % of patients with schizophrenia having overall CAN compared to 27.2 % among controls. Dividing patients into patients with first-episode and chronic schizophrenia, 32.9 % vs 10 % (p < 0.001) and 59.1 % vs 41 % (p < 0.001) had overall CAN compared with controls, respectively. Schizophrenia was significantly associated with overall CAN (OR, 2.80; 95%CI, 1.75-4.50), with an OR of 2.31 (95%CI, 1.14-4.68) for first-episode schizophrenia and an OR of 2.97 (95%CI, 1.81-4.87) for chronic schizophrenia.<BR><B>UNASSIGNED: </B>It was demonstrated that a diagnosis of schizophrenia was associated with CAN. Patients with chronic schizophrenia had a significantly higher prevalence of CAN compared to patients with first-episode schizophrenia, suggesting an association between the duration of schizophrenia and CAN.