关键词: AIDS HIV Toxoplasma gondii meta-analysis ocular toxoplasmosis retinochoroiditis

Mesh : Humans HIV Infections / epidemiology complications drug therapy Prevalence Toxoplasmosis, Ocular / epidemiology Male Female Toxoplasma

来  源:   DOI:10.2217/fmb-2023-0215

Abstract:
Aim: To determine the prevalence of ocular toxoplasmosis among people living with HIV through a systematic review and meta-analysis. Materials & methods: A literature search was conducted, estimating pooled prevalence and performing quality assessment, outlier, influential and meta-regression analyses. Results: Twenty-nine studies were included in the analysis, revealing that the rate of ocular toxoplasmosis among people living with HIV was 0.37% (95% CI: 0.2-0.6). Substantial heterogeneity was observed among the studies. Despite analyzing continuous variables, including year of publication, proportion of males, mean age and proportion of patients receiving antiretroviral therapy, no statistically significant associations were found. Conclusion: This study provides an overview of the prevalence of ocular toxoplasmosis in people living with HIV, emphasizing the need for further research to uncover factors contributing to its development.
This study looked at how common ocular toxoplasmosis, a type of parasitic infection, is among people living with HIV. We did this by reviewing other studies, combining their results and evaluating the quality of each study. We also looked for any unusual findings and other factors that might affect the prevalence of ocular toxoplasmosis. After analyzing 29 studies, we found that approximately 0.37% of people living with HIV had ocular toxoplasmosis, ranging from 0.2% to 0.6%. There was a significant variation in the results among the studies. Our study provides an overview of the prevalence of ocular toxoplasmosis in people living with HIV, highlighting the need for further research to identify the factors contributing to its development.
摘要:
目的:通过系统评价和荟萃分析,确定HIV感染者中眼弓形虫病的患病率。材料与方法:进行了文献检索,估计合并患病率并进行质量评估,离群值,有影响力和荟萃回归分析。结果:29项研究纳入分析,结果显示,HIV感染者的眼弓形虫病率为0.37%(95%CI:0.2-0.6).在研究中观察到显著的异质性。尽管分析了连续变量,包括出版年份,男性的比例,接受抗逆转录病毒治疗的患者的平均年龄和比例,没有发现有统计学意义的关联.结论:本研究概述了HIV感染者眼弓形虫病的患病率,强调需要进一步研究以发现促成其发展的因素。
这项研究观察了常见的眼部弓形虫病,一种寄生虫感染,是艾滋病毒携带者中的一员。我们通过回顾其他研究来做到这一点,结合他们的结果并评估每个研究的质量。我们还寻找了可能影响眼弓形虫病患病率的任何异常发现和其他因素。在分析了29项研究后,我们发现大约0.37%的艾滋病毒感染者患有眼部弓形虫病,0.2%至0.6%不等。研究结果之间存在显着差异。我们的研究概述了HIV感染者中眼部弓形虫病的患病率,强调需要进一步研究,以确定有助于其发展的因素。
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