Abstract：
The objective of the present study is to assess the rates of acquired tolerance to cow\'s milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF-S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.
摘要：
本研究的目的是评估作为PRESTO研究的一部分(荷兰试验登记号NTR3725),在生命早期1年干预期间,食用含有合生元的基于氨基酸的配方(AAF-S)或不含合生元的基于氨基酸的配方(AAF)的受试者36个月后对牛奶(CM)的获得性耐受率。使用逻辑回归模型分析了组间CM耐受性发展的差异。结果表明，受试者的比例(平均[±SD]年龄，3.8±0.27年）在36个月后出现CM耐受性的患者在接受AAF-S（47/60[78％]）和接受AAF（49/66[74％]）的组中相似（p=0.253），也就是说,与CM过敏的自然产物相当。我们的数据表明，消耗AAF和不暴露于CM肽不会减慢CM耐受性的获得。
