PDF(Pubmed)
Abstract：
BACKGROUND: Sebaceous carcinoma is a very rare malignant skin adnexal tumor that is occasionally aggressive. We have not seen a case of sebaceous carcinoma in our center in the last 10 years. It is extremely rare in Black Africans.
METHODS: We described the case of a 55-year-old man African man who presented to our ophthalmologist with complaints of growth on the right upper eyelid for 8 months. He had surgery and chemotherapy for rectal carcinoma 6 years prior to presentation and received his last dose of chemotherapy 5 years before seeing our ophthalmologist. There was a history of spontaneous unprovoked bleeding from the lesion. He subsequently underwent surgical excision under general anesthesia. Histology of the mass showed an effaced architecture due to proliferating malignant epithelial cells disposed as trabecules, solid nests, and tongues. The microscopic features of widespread multivacuolated cytoplasm of the neoplastic cells led us to conclude that the tumor was a sebaceous carcinoma. The patient is alive and well.
CONCLUSIONS: Sebaceous carcinoma is a rare malignant skin adnexal tumor in Black Africans. It can present as an eyelid mass with spontaneous bleeding. It can follow cancer chemotherapy either because of its association with other tumors in Muir-Torre syndrome or because of mutagenic effects of chemotherapeutic agents.
METHODS: We described the case of a 55-year-old man African man who presented to our ophthalmologist with complaints of growth on the right upper eyelid for 8 months. He had surgery and chemotherapy for rectal carcinoma 6 years prior to presentation and received his last dose of chemotherapy 5 years before seeing our ophthalmologist. There was a history of spontaneous unprovoked bleeding from the lesion. He subsequently underwent surgical excision under general anesthesia. Histology of the mass showed an effaced architecture due to proliferating malignant epithelial cells disposed as trabecules, solid nests, and tongues. The microscopic features of widespread multivacuolated cytoplasm of the neoplastic cells led us to conclude that the tumor was a sebaceous carcinoma. The patient is alive and well.
CONCLUSIONS: Sebaceous carcinoma is a rare malignant skin adnexal tumor in Black Africans. It can present as an eyelid mass with spontaneous bleeding. It can follow cancer chemotherapy either because of its association with other tumors in Muir-Torre syndrome or because of mutagenic effects of chemotherapeutic agents.
摘要：
背景：皮脂腺癌是一种非常罕见的恶性皮肤附件肿瘤，偶尔具有侵袭性。在过去的10年中，我们中心没有看到皮脂腺癌的病例。这在非洲黑人中极为罕见。
方法：我们描述了一个55岁的非洲男子的案例，他向我们的眼科医生提出了8个月的右上眼睑生长的抱怨。他在就诊前6年接受了直肠癌的手术和化疗，并在见到我们的眼科医生前5年接受了最后一次化疗。有自发无源性出血的病史。随后，他在全身麻醉下接受了手术切除。肿块的组织学显示，由于恶性上皮细胞以小梁的形式增殖，结构已消失。固体巢，和舌头。肿瘤细胞广泛的多刺激细胞质的微观特征使我们得出结论，该肿瘤是皮脂腺癌。病人活得很好。
结论：皮脂腺癌是非洲黑人罕见的恶性皮肤附件肿瘤。它可以表现为自发出血的眼睑肿块。由于其与Muir-Torre综合征中的其他肿瘤相关或由于化学治疗剂的诱变作用，可以跟随癌症化疗。
方法：我们描述了一个55岁的非洲男子的案例，他向我们的眼科医生提出了8个月的右上眼睑生长的抱怨。他在就诊前6年接受了直肠癌的手术和化疗，并在见到我们的眼科医生前5年接受了最后一次化疗。有自发无源性出血的病史。随后，他在全身麻醉下接受了手术切除。肿块的组织学显示，由于恶性上皮细胞以小梁的形式增殖，结构已消失。固体巢，和舌头。肿瘤细胞广泛的多刺激细胞质的微观特征使我们得出结论，该肿瘤是皮脂腺癌。病人活得很好。
结论：皮脂腺癌是非洲黑人罕见的恶性皮肤附件肿瘤。它可以表现为自发出血的眼睑肿块。由于其与Muir-Torre综合征中的其他肿瘤相关或由于化学治疗剂的诱变作用，可以跟随癌症化疗。
